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. 2022 May 1;18(8):3209–3222. doi: 10.7150/ijbs.70289

Figure 2.

Figure 2

Exosomes derived from renal cancer cells promote macrophage polarization and tumor development in vivo. A. Schematic of RCC nude mice model. B. Comparison of the tumor volume among three groups: normal control, Caki only, and Exo+Caki. ***P<0.001. C-D. Flow cytometry analysis of macrophage phenotypes in mice groups treated or not treated with exosomes. E. Representative IHC images of tumor tissues from Caki and Exo+Caki mice or kidney from NC mice to demonstrate the expression of F4/80, CD206and ki67. ***P<0.001. F. Quantitative analysis of ISH of F4/80, CD 206 and ki67 among three groups. ***P<0.001.