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. 2022 May 1;18(8):3209–3222. doi: 10.7150/ijbs.70289

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This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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LncARSR promotes the development of RCC through transmit by exosomes to macrophages. A- B. Through animal fluorescence quantitative analysis, we found that the MFI of nude mouse tumors in exosome pretreatment group was significantly higher than the MFI value in no pretreatment group, lncARSR-knockdown pretreatment group, and the control after 3 weeks pretreatment (***P<0.001). C-D. We detected the expression of F4/80, CD206 and Ki67 in tumor specimens of nude mice by immunohistochemistry. The expression levels of F4/80, CD206 and Ki67 of tumor tissue were higher in exosome pretreatment group than those in lncARSR-knockdown pretreatment group, no pretreatment group and the control (**P<0.01, ***P<0.001).