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. 2022 May 1;18(8):3167–3177. doi: 10.7150/ijbs.69155

Figure 4.

Figure 4

SNCG promotes cell migration and invasion through p38MAPK. (A) HepG2 cells were transfected with 1 μg/ml of the empty vector or SNCG expression plasmid, and then treated with or without 50 μM of SB203580 for another 24h, followed by wound healing assays. The relative wound closure rate was plotted. Values represent mean ± SD (n = 3). *, p < 0.05. **, p <0.01. ***, p <0.001. In parallel, the efficiency of SNCG overexpresion was detected by western blot analysis. (B-C) HepG2 or HeLa cells were transfected with the empty vector or SNCG plasmid, and then transfected with siControl or siP38α, followed by wound healing assays. Values represent mean ± SD (n = 3). *, p < 0.05. **, p <0.01. ***, p <0.001. In parallel, the efficiency of SNCG overexpresion and p38α knockdown was detected by western blot analysis. (D-E) HepG2 or HeLa cells were transfected with the empty vector or SNCG plasmid, and then transfected with siControl or siP38α, followed by cell invasion assays. The relative cell invasion rate was plotted. Values represent mean ± SD (n = 3). The invasion rate in vehicle-treated and vector-transfected cells was set as 1. *, p < 0.05. **, p <0.01. ***, p <0.001, compared with vehicle-treated and vector-transfected cells. In parallel, the efficiency of SNCG overexpresion and p38α knockdown was detected by western blot analysis.