. 2022 May 1;18(8):3194–3208. doi: 10.7150/ijbs.69671

Table 1.

List of ncRNA-target and the type of interaction present in networks.

ncRNA	Name	Direct target	Direct effect	PMID	Function*
miRNA	let-7i	FASLG	neg	28350318	anti-apoptosis
miRNA	let-7i	CCND2	neg	30679264	Inhibition of cell proliferation
miRNA	let-7i	E2F2	neg	30679264	Inhibition of cell proliferation
miRNA	miR-124	HIC5	neg	29864957	Pro-apoptosis
miRNA	miR-124	DHCR24	neg	31100313	Pro-apoptosis
miRNA	miR-125b	BAK1	neg	29122578	Anti-apoptosis
miRNA	miR-125b	KLF13	neg	29122578
miRNA	miR-125b	p53	neg	29921652
miRNA	miR-125b	p53	neg	30613290
miRNA	miR-125b	BAK1	neg	30613290
miRNA	miR-142	APC	neg	32327611	Anti-apoptosis Activation of cardiac fibroblasts
miRNA	miR-142	TP53INP1	neg	31085811	Anti-apoptosis Activation of cardiac fibroblasts
miRNA	miR-143	IGF-IR	neg	32368046	Pro-angiogenesis
miRNA	miR-143	ERG1	neg	31900593	Inhibition ventricular arrhythmias
miRNA	miR-143	SPRY3	neg	30878395	Pro-fibrosis
miRNA	miR-144	mTOR	neg	30084039	Pro-fibrosis
miRNA	miR-144	PTEN	neg	31737623	Pro-autophagy
miRNA	miR-152	DNMT1	neg	29358670	Promotion of cell proliferation
miRNA	miR-152	p27	neg	29358670
miRNA	miR-152	ATG12	neg	28350318
miRNA	miR-155	SOS1	neg	28129114	Anti-fibrosis
miRNA	miR-155	SOCS1	neg	28129114	Anti-fibrosis
miRNA	miR-155	QKI	neg	31191799	Pro-apoptosis
miRNA	miR-155	RAC1	neg	32112145	Anti-angiogenesis
miRNA	miR-155	PAK2	neg	32112145
miRNA	miR-155	SIRT1	neg	32112145
miRNA	miR-155	AMPKα2	neg	32112145
miRNA	miR-181a	STAT1	neg	28597963	Anti-inflammation, Anti-apoptosis
miRNA	miR-181a	c-Fos	neg	28597963	Anti-inflammation, Anti-apoptosis
miRNA	miR-181a	ADAMTS1	neg	32304626	Inhibition of cardiomyocytes hypertrophy
miRNA	miR-199a	HOMER1	neg	28077443	Promotion of cell proliferation
miRNA	miR-199a	HOPX	neg	30125571	Promotion of cell proliferation
miRNA	miR-21	PTEN	neg	26978580	Anti-apoptosis
miRNA	miR-21	KBTBD7	neg	29991775	Anti-inflammation
miRNA	miR-21	PDCD4	neg	31149048	Anti-apoptosis
miRNA	miR-21	PDCD4	neg	30684569
miRNA	miR-21	PTEN	neg	30684569
miRNA	miR-21	STRN	neg	32297634	Disorder of nitrogen metabolism
miRNA	miR-21	SPRY1	neg	33273841	Pro-fibrosis
miRNA	miR-210	CXCR4	neg	29710553	Reduction of hypoxia-induced damage
miRNA	miR-210	AIFM3	neg	32513270	Anti-apoptosis
miRNA	miR-210	EFNA3	neg	28249798	Pro-angiogenesis
miRNA	miR-214	DIO3	neg	27014189	Protection of cardiac systolic function
miRNA	miR-214	PTEN	neg	29584819	Promotion of cell proliferation
miRNA	miR-214	PTEN	neg	30545799	Promotion of cell proliferation
miRNA	miR-214	GSK3β	neg	30947518	Promotion of cardiac regeneration
miRNA	miR-221	PTEN	neg	32586406	Pro-angiogenesis Anti-apoptosis
miRNA	miR-221	PTEN	neg	32432109	Pro-angiogenesis Anti-apoptosis
miRNA	miR-221	FOXO3	neg	32629000	Anti-fibrosis
miRNA	miR-26a	ATM	neg	31990056	Anti-apoptosis, Anti-fibrosis
miRNA	miR-26a	USP15	neg	31512556	Pro-autophagy
miRNA	miR-26a	BAK1	neg	32464547	Anti-apoptosis
miRNA	miR-590	CLIC5	neg	28077443	Promotion of cell proliferation
miRNA	miR-590	HOMER1	neg	28077443	Promotion of cell proliferation
miRNA	miR-590	ZEB1	neg	31675172	Anti-fibrosis
miRNA	miR-92a	KLF2	neg	32939962	Anti-angiogenesis
miRNA	miR-92a	ATG4A	neg	30571345	Anti-autophagy
miRNA	miR-92a	ABCA8B	neg	30571345	Lipometabolic disturbance
miRNA	miR-92a	CD36	neg	30571345	Lipometabolic disturbance
lncRNA	AZIN2-sv	miR-214	neg	29584819	Inhibition of cell proliferation
lncRNA	AZIN2-sv	PTEN	pos	29584819
lncRNA	AZIN2-sv	miR-214	neg	30545799
lncRNA	AZIN2-sv	TLN1	neg	30545799	Anti-angiogenesis
lncRNA	GAS5	SEMA3A	neg	30099044	Anti-apoptosis
lncRNA	GAS5	miR-142	neg	31085811	Pro-apoptosis
lncRNA	H19	YB-1	neg	31588235	Pro-fibrosis
lncRNA	H19	miR-22	neg	31755219	Reduction of cardiomyocytes damage
lncRNA	H19	miR-675	pos	31119268	Anti-apoptosis, Pro-angiogenesis
lncRNA	KCNQ1OT1	RUNX3	neg	31625414	Pro-inflammation
lncRNA	KCNQ1OT1	DNMT1	pos	31625414	Pro-apoptosis
lncRNA	KCNQ1OT1	miR-466k	neg	32422306	Cardiomyocytes damage
lncRNA	KCNQ1OT1	miR-466i	neg	32422306	Cardiomyocytes damage
lncRNA	MALAT1	miR-320	neg	29990866	Pro-apoptosis
lncRNA	MALAT1	miR-558	neg	30536615	Anti-apoptosis
lncRNA	MALAT1	miR-497	neg	32393784	Anti-apoptosis
lncRNA	MALAT1	miR-145	neg	30146700	Pro-fibrosis
lncRNA	MALAT1	miR-92a	neg	32939962	Pro-angiogenesis
lncRNA	MEG3	FUS	pos	30287867	Pro-apoptosis
lncRNA	MEG3	p53	pos	31631486	Pro-apoptosis
lncRNA	TUG1	miR-124	neg	29864957	Anti-apoptosis
lncRNA	TUG1	miR-9a	neg	31787746	Pro-apoptosis
circRNA	circHIPK3	miR-17	neg	31595165	Increase of Ca²⁺ in cardiomyocytes
circRNA	circHIPK3	N1ICD	pos	32736292	Promotion of cell proliferation
circRNA	circHIPK3	miR-133a	neg	32736292	Pro-angiogenesis
circRNA	circHIPK3	miR-29a	neg	32733638	Pro-angiogenesis

* Function refers to the pathophysiological changes after MI caused by upregulation of the ncRNA expression.