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. 2022 May 9;18(8):3337–3357. doi: 10.7150/ijbs.69141

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NETs activate METTL3-mediated m6A modification in alveolar epithelial cells. RNA-Seq identified METTL3 upregulation in NETs-treated alveolar epithelial cells. (B) GO and KEGG analyses. (C) m6A modification-related genes were confirmed by qRT-PCR. (D) The upregulated METTL3 protein in NETs-treated alveolar epithelial cells was confirmed by IF (green: METTL3, blue: DAPI). (E) The total level of m6A-methylated RNA was analyzed using a colorimetric kit and (F) the dot blot assay. *P<0.05, **P<0.01. (Two-way ANOVA with Tukey's correction).