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. 2022 May 9;18(8):3337–3357. doi: 10.7150/ijbs.69141

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NETs induced ferroptosis in alveolar epithelial cells. (A) RNA-Seq+M6a-RIP-Seq identified GPX4 modification enrichment in alveolar epithelial cells. (B) METTL3 and GPX4 mRNA were analyzed by qRT-PCR. (C) METTL3 and GPX4 protein were analyzed by Western blotting. (D) m6A-methylated GPX4 mRNA was analyzed by Me-RIP-QPCR. (E) Curve and statistical analysis of GPX4 mRNA half-life after transfection with METTL3 siRNA, METTL3-WT, METTL3-Mut or the negative control after transcription inhibition (TI) are shown. *P<0.05 (two-way ANOVA with Tukey's correction).