Table 1. . Dose escalation schema to be used prior to the occurrence of first grade ≥2 toxicity classified as possibly related to study drug.

Dose escalation schedule
Dose level	Proposed dose of WP1066 as API in mg/kg†
Level 1	1
Level 2	2
Level 3	4
Level 4	8
Level 5	16

^†Doses are stated as exact total dose (e.g., mg/kg) administered BID.

API: Active pharmaceutical ingredient.