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. 2022 May 6;14(9):4036–4049. doi: 10.18632/aging.204070

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Copyright: © 2022 Xu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Bioinformatics analysis indicated the potential association between PTX3 and HF progression. (A) Kaplan-Meier analysis in GEO database showed that the up-regulation of PTX3 was associated with a lower overall survival rate. (B) PTX3 in tissues from HF patients was up-regulated compared with that in normal tissues. (C) Volcano plot and (D) heatmap of the PTX3-induced DEGs; red indicates the up-regulated genes and blue indicates the down-regulated genes. (E) Protein-protein interaction network of DEGs. (F) GSEA showed a significant correlation between PTX3 expression and the pathways related to IL-6 production. (G) GO analysis and (H) KEGG analysis revealed the representative enrichment pathways.