Table 2.

In vitro activity of MRX-8 and other comparator agents against 138 of Klebsiella pneumoniae (mg/L).

Isolates	Antimicorbial agents	MIC (mg/liter)			R, %	S, %
		Range	50%	90%
polymyxin non-resistant and carbapenem-susceptible Klebsiella pneumoniae (n = 46)	MRX-8	0.06-0.5	0.25	0.5	0	100
	Polymyxin B	0.25-1	0.25	0.5	0	100
	Colistin	0.25-1	0.25	0.5	0	100
	Amikacin	0.5-8	1	2	0	100
	Ceftriaxone	0.06->64	0.06	>64	19.6	80.4
	Ceftazidime	0.125-64	0.5	8	8.7	82.6
	Cefepime	0.06-64	0.125	8	17.4	80.4
	Ceftazidime-avibactam	0.06-0.5	0.25	0.5	0	100
	Cefoperazone-sulbactam	0.125-64	0.5	32	2.2	89.1
	Meropenem	0.06-0.06	0.06	0.06	0	100
	Ciprofloxacin	0.06->64	0.125	32	28.3	69.6
polymyxin non-resistant and carbapenem-resistant Klebsiella pneumoniae (n = 60)	MRX-8	0.06-2	0.125	0.5	0	100
	Polymyxin B	0.125-2	0.25	1	0	100
	Colistin	0.125-1	0.25	0.5	0	100
	Amikacin	0.25->64	>64	>64	76.7	23.3
	Ceftriaxone	>64->64	>64	>64	100	0
	Ceftazidime	64->64	>64	>64	100	0
	Cefepime	32->64	>64	>64	100	0
	Ceftazidime-avibactam	1->64	2	>64	21.7	76.7
	Cefoperazone-sulbactam	>64->64	>64	>64	100	0
	Meropenem	32-32	32	32	100	0
	Ciprofloxacin	≤0.06->64	64	>64	98.3	1.7
Polymyxin-resistant Klebsiella pneumoniae (n = 32)	MRX-8	2->32	16	>32	91.6	9.4
	Polymyxin B	4->32	16	>32	100	0
	Colistin	8->8	>8	>8	100	0
	Amikacin	1->64	>64	>64	78.1	21.9
	Ceftriaxone	0.125->64	>64	>64	96.9	3.1
	Ceftazidime	0.5->64	>64	>64	93.8	6.2
	Cefepime	0.125->64	>64	>64	93.8	6.2
	Ceftazidime-avibactam	0.25->64	2	4	6.2	93.8
	Cefoperazone-sulbactam	1->64	>64	>64	84.4	3.1
	Meropenem	≤0.06->16	>16	>16	78.1	21.9
	Ciprofloxacin	≤0.06->64	>64	>64	87.5	12.5

R, resistant; S, susceptible. All the intermediate data were not showed in table.