Table 3.
In vitro activity of MRX-8 and other comparator agents against 187 of other Enterobacterales (mg/L).
| Isolates | Antimicorbial agents | MIC (mg/liter) | R, % | S, % | ||
|---|---|---|---|---|---|---|
| Range | 50% | 90% | ||||
| Other Klebsiella spp.(n = 25) | MRX-8 | 0.06->32 | 0.125 | 0.125 | 4 | 96 |
| Polymyxin B | 0.125->32 | 0.25 | 0.5 | 4 | 96 | |
| Colistin | 0.125->8 | 0.25 | 0.5 | 4 | 96 | |
| Amikacin | 0.5-2 | 1 | 2 | 0 | 100 | |
| Ceftriaxone | ≤0.06->64 | 0.25 | >64 | 28 | 72 | |
| Ceftazidime | 0.125->64 | 0.25 | >64 | 24 | 76 | |
| Cefepime | ≤0.06->64 | ≤0.06 | 64 | 20 | 80 | |
| Ceftazidime-avibactam | ≤0.06->64 | 0.125 | >64 | 16 | 84 | |
| Cefoperazone-sulbactam | 0.125->64 | 1 | >64 | 16 | 84 | |
| Meropenem | ≤0.06-32 | ≤0.06 | 16 | 12 | 84 | |
| Ciprofloxacin | ≤0.06-4 | ≤0.06 | 1 | 16 | 80 | |
| Citrobacter spp. (n = 25) | MRX-8 | 0.03->32 | 0.125 | 0.25 | 8 | 92 |
| Polymyxin B | 0.25->32 | 0.5 | 1 | 8 | 92 | |
| Colistin | 0.25->8 | 0.5 | 1 | 8 | 92 | |
| Amikacin | 0.5-16 | 1 | 2 | 0 | 100 | |
| Ceftriaxone | ≤0.06->64 | 1 | >64 | 44 | 56 | |
| Ceftazidime | 0.125->64 | 1 | >64 | 44 | 52 | |
| Cefepime | ≤0.06->64 | 0.06 | 64 | 24 | 64 | |
| Ceftazidime-avibactam | ≤0.06->64 | 0.25 | >64 | 16 | 84 | |
| Cefoperazone-sulbactam | ≤0.06->64 | 1 | >64 | 28 | 64 | |
| Meropenem | ≤0.06->16 | 0.06 | >16 | 16 | 84 | |
| Ciprofloxacin | ≤0.06-32 | 0.06 | 16 | 32 | 68 | |
| Morganella spp. (n = 25) | MRX-8 | 32->32 | >32 | >32 | 100 | 0 |
| Polymyxin B | >32->32 | >32 | >32 | 100 | 0 | |
| Colistin | >8->8 | >8 | >8 | 100 | 0 | |
| Amikacin | 1-16 | 4 | 8 | 0 | 100 | |
| Ceftriaxone | ≤0.06->64 | 1 | 32 | 36 | 52 | |
| Ceftazidime | ≤0.06->64 | 2 | 64 | 24 | 72 | |
| Cefepime | ≤0.06->64 | 0.06 | 8 | 12 | 84 | |
| Ceftazidime-avibactam | ≤0.06-1 | 0.06 | 0.25 | 0 | 100 | |
| Cefoperazone-sulbactam | 0.5-16 | 2 | 16 | 0 | 100 | |
| Meropenem | ≤0.06-0.25 | 0.125 | 0.25 | 0 | 100 | |
| Ciprofloxacin | ≤0.06->64 | 0.125 | 16 | 40 | 60 | |
| Proteus spp. (n = 25) | MRX-8 | >32->32 | >32 | >32 | 100 | 0 |
| Polymyxin B | >32->32 | >32 | >32 | 100 | 0 | |
| Colistin | >8->8 | >8 | >8 | 100 | 0 | |
| Amikacin | 1-32 | 4 | 32 | 0 | 88 | |
| Ceftriaxone | ≤0.06->64 | 4 | >64 | 64 | 32 | |
| Ceftazidime | ≤0.06-32 | 0.125 | 4 | 4 | 96 | |
| Cefepime | ≤0.06->64 | 0.125 | 64 | 32 | 60 | |
| Ceftazidime-avibactam | ≤0.06-0.25 | ≤0.06 | 0.125 | 0 | 100 | |
| Cefoperazone-sulbactam | 0.5-8 | 2 | 8 | 0 | 100 | |
| Meropenem | ≤0.06-1 | 0.125 | 0.25 | 0 | 100 | |
| Ciprofloxacin | ≤0.06-64 | 4 | 64 | 52 | 40 | |
| Providencia spp. (n = 25) | MRX-8 | >64->64 | >64 | >64 | 100 | 0 |
| Polymyxin B | >64->64 | >64 | >64 | 100 | 0 | |
| Colistin | >8->8 | >8 | >8 | 100 | 0 | |
| Amikacin | 0.25->64 | 2 | 16 | 8 | 92 | |
| Ceftriaxone | ≤0.06->64 | 0.5 | >64 | 36 | 64 | |
| Ceftazidime | ≤0.06->64 | 2 | >64 | 40 | 56 | |
| Cefepime | ≤0.06->64 | 0.5 | >64 | 40 | 52 | |
| Ceftazidime-avibactam | ≤0.06->64 | 0.125 | >64 | 20 | 80 | |
| Cefoperazone-sulbactam | 0.125->64 | 4 | >64 | 20 | 76 | |
| Meropenem | ≤0.06-32 | 0.125 | 16 | 16 | 80 | |
| Ciprofloxacin | ≤0.06-32 | 4 | 16 | 52 | 36 | |
| Serratia Spp. (n = 25) | MRX-8 | >32->32 | >32 | >32 | 100 | 0 |
| Polymyxin B | >32->32 | >32 | >32 | 100 | 0 | |
| Colistin | >8->8 | >8 | >8 | 100 | 0 | |
| Amikacin | 1-8 | 2 | 4 | 0 | 100 | |
| Ceftriaxone | 0.25->64 | 0.5 | 64 | 24 | 76 | |
| Ceftazidime | 0.125-16 | 0.5 | 4 | 4 | 92 | |
| Cefepime | ≤0.06->64 | 0.25 | >64 | 16 | 80 | |
| Ceftazidime-avibactam | ≤0.06-1 | 0.25 | 1 | 0 | 100 | |
| Cefoperazone-sulbactam | 0.5->64 | 4 | 64 | 12 | 80 | |
| Meropenem | ≤0.06->16 | ≤0.06 | >16 | 12 | 88 | |
| Ciprofloxacin | ≤0.06-8 | 0.125 | 8 | 24 | 76 | |
| Salmonella spp. (n = 17) | MRX-8 | 0.06-4 | 0.25 | 0.25 | 5.9 | 94.1 |
| Polymyxin B | 0.125-4 | 0.25 | 0.5 | 5.9 | 94.1 | |
| Colistin | 0.125-4 | 0.5 | 1 | 5.9 | 94.1 | |
| Amikacin | 0.25-4 | 1 | 2 | 0 | 100 | |
| Ceftriaxone | ≤0.06->64 | 0.125 | 32 | 17.6 | 82.4 | |
| Ceftazidime | 0.125->64 | 0.5 | 64 | 17.6 | 82.4 | |
| Cefepime | ≤0.06-32 | 0.125 | 1 | 5.9 | 94.1 | |
| Ceftazidime-avibactam | ≤0.06-1 | 0.25 | 0.5 | 0 | 100 | |
| Cefoperazone-sulbactam | 0.5-32 | 1 | 32 | 0 | 88.2 | |
| Meropenem | ≤0.06-0.125 | 0.06 | 0.06 | 0 | 100 | |
| Ciprofloxacin | ≤0.06-1 | 0.25 | 1 | 23.5 | 0 | |
| Shigella spp. (n = 20) | MRX-8 | 0.03-0.125 | 0.06 | 0.06 | 0 | 100 |
| Polymyxin B | 0.125-0.25 | 0.25 | 0.25 | 0 | 100 | |
| Colistin | 0.125-0.25 | 0.25 | 0.25 | 0 | 100 | |
| Amikacin | 2-4 | 2 | 4 | 0 | 100 | |
| Ceftriaxone | ≤0.06->64 | 0.06 | 128 | 40 | 60 | |
| Ceftazidime | ≤0.06-32 | 0.25 | 8 | 10 | 85 | |
| Cefepime | ≤0.06-64 | 0.5 | 16 | 40 | 60 | |
| Ceftazidime-avibactam | ≤0.06-0.25 | ≤0.06 | 0.125 | 0 | 100 | |
| Cefoperazone-sulbactam | 0.25-32 | 2 | 16 | 0 | 90 | |
| Meropenem | ≤0.06 -≤0.06 | ≤0.06 | ≤0.06 | 0 | 100 | |
| Ciprofloxacin | 0.125-16 | 0.25 | 16 | 50 | 50 | |
R, resistant; S, susceptible. All the intermediate data were not showed in table.