Table 4.
In vitro activity of MRX-8 and other comparator agents against 100 of Pseudomonas aeruginosa (mg/L).
| Isolates | Antimicorbial agents | MIC (mg/liter) | R, % | S, % | ||
|---|---|---|---|---|---|---|
| Rang | 50% | 90% | ||||
| carbapenem-susceptible Pseudomonas aeruginosa (n = 46) | MRX-8 | 0.125-2 | 1 | 1 | 0 | 100 |
| Polymyxin B | 0.25-2 | 1 | 1 | 0 | 100 | |
| Colistin | 0.25-2 | 1 | 1 | 0 | 100 | |
| Amikacin | 0.25-8 | 4 | 8 | 0 | 100 | |
| Ceftazidime | 0.125-64 | 2 | 8 | 4.3 | 95.7 | |
| Cefepime | 0.06-32 | 2 | 8 | 2.2 | 95.7 | |
| Ceftazidime-avibactam | 0.06-8 | 2 | 2 | 4.3 | 95.7 | |
| Cefoperazone-sulbactam | 1-64 | 8 | 16 | – | – | |
| Meropenem | 0.06-2 | 0.125 | 0.5 | 0 | 100 | |
| Ciprofloxacin | 0.06-4 | 0.125 | 0.5 | 6.5 | 91.3 | |
| carbapenem-resistant Pseudomonas aeruginosa (n = 54) | MRX-8 | 0.5->32 | 1 | 1 | 1.9 | 98.1 |
| Polymyxin B | 0.5->32 | 1 | 1 | 1.9 | 98.1 | |
| Colistin | 0.5->8 | 1 | 1 | 1.9 | 98.1 | |
| Amikacin | 1->64 | 4 | 16 | 9.3 | 90.7 | |
| Ceftazidime | 4->64 | 32 | >64 | 59.3 | 20.4 | |
| Cefepime | 4->64 | 16 | 64 | 42.6 | 25.9 | |
| Ceftazidime-avibactam | 2->64 | 8 | 32 | 72.2 | 27.8 | |
| Cefoperazone-sulbactam | 16->64 | 64 | >64 | – | – | |
| Meropenem | 8->16 | 16 | >16 | 100 | 0 | |
| Ciprofloxacin | 0.06->64 | 1 | 32 | 40.7 | 38.9 | |
R, resistant; S, susceptible. All the intermediate data were not showed in table.