Table 5.
In vitro activity of MRX-8 and other comparator agents against 113 of Acinetobacter baumannii (mg/L).
| Isolates | Antimicorbial agents | MIC (mg/liter) | R, % | S, % | ||
|---|---|---|---|---|---|---|
| Range | 50% | 90% | ||||
| carbapenem-susceptible Acinetobacter baumannii (n = 43) | MRX-8 | 0.125->32 | 0.5 | 0.5 | 4.7 | 95.3 |
| Polymyxin B | 0.5->32 | 0.5 | 0.5 | 4.7 | 95.3 | |
| Colistin | 0.5-16 | 0.5 | 0.5 | 4.7 | 95.3 | |
| Amikacin | 0.5-16 | 2 | 4 | 0 | 100 | |
| Ceftazidime | 0.5-8 | 4 | 4 | 0 | 100 | |
| Cefepime | 0.25-4 | 2 | 4 | 0 | 100 | |
| Ceftazidime-avibactam | 0.125-8 | 4 | 4 | – | – | |
| Cefoperazone-sulbactam | 1-4- | 2 | 4 | – | – | |
| Meropenem | 0.06-0.5 | 0.25 | 0.25 | 0 | 100 | |
| Ciprofloxacin | 0.06-64 | 0.125 | 8 | 14 | 86 | |
| carbapenem-resistant Acinetobacter baumannii (n = 70) | MRX-8 | 0.25->32 | 0.5 | 1 | 2.9 | 97.1 |
| Polymyxin B | 0.25->32 | 0.5 | 1 | 2.9 | 97.1 | |
| Colistin | 0.25->8 | 0.5 | 1 | 2.9 | 97.1 | |
| Amikacin | 2->64 | >64 | >64 | 87.1 | 12.9 | |
| Ceftazidime | 64->64 | >64 | >64 | 100 | 0 | |
| Cefepime | 8->64 | >64 | >64 | 95.7 | 1.4 | |
| Ceftazidime-avibactam | 1->64 | 64 | 64 | – | – | |
| Cefoperazone-sulbactam | 8->64 | >64 | >64 | – | – | |
| Meropenem | 16->16 | >16 | >16 | 100 | 0 | |
| Ciprofloxacin | 32->64 | 64 | >64 | 100 | 0 | |
R, resistant; S, susceptible. All the intermediate data were not showed in table.