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Serum LH levels in response to GnRHa therapy. Prior to medical transition, LH exhibits pulsatile secretion in response to its upstream stimulator, GnRH. With treatment with GnRHa, LH levels initially increase during a “flare‐up” followed by a “desensitization” phase leading to gonadotrope suppression and loss of LH pulsatility. Adapted from Ref. 42. LH, Luteinizing Hormone; GnRH, Gonadotropin‐releasing hormone; GnRHa, Gonadotropin‐releasing hormone Analog
