Table 1. Pharmacological and procedural recommendations for treatment of knee osteoarthritis.

NSAID=non-steroidal anti-inflammatory drug, I-CS=intra-articular corticosteroid, I-HA=intra-articular hyaluronic acid, SNRI=Serotonin and norepinephrine reuptake inhibitors, I-PRP=intra-articular platelet-rich plasma

Society	Recommended	Inconclusive	Not recommended
American Academy of Orthopedic Surgeons	Topical NSAIDs Oral NSAIDs Tramadol	Acetaminophen Nontramadol opioids I-CS I-PRP	Chondroitin Glucosamine I-HA
Osteoarthritis Research Society International	Topical NSAIDs Capsaicin Acetaminophen (in patients without comorbidities) Oral NSAIDs ( in patients without comorbidities) SNRI (i.e. duloxetine in patient without comorbidities) I-CS	Chondroitin (for symptom relief) Glucosamine (for symptom relief) Opioids I-HA	Chondroitin (for disease modification) Glucosamine (for disease modification)
American college of Rheumatology	Topical NSAIDs Acetaminophen Oral NSAIDs Tramadol I-CS	SNRIs (i.e. duloxetine) Nontramadol opioids I-HA	Topical capsaicin Glucosamine Chondroitin