Table 1. Contingency table.

Annotated Gene-sets	DEGs (proposed)	EEGs (proposed)	Marginal total (Annotated)
ith GO term/KEGG pathway (Si)	k i	M i —k i	M i
Complement of Si ($S_{\mathit{i}}^c$)	n—k i	N—M i −n + k i	N—M i
Marginal total	n	N—n	N (Grand total)