Table 3. Significantly enriched GO functions and KEGG pathways by the DEGs involving KGs that were also supported by the literature review about their association with BC and other cancers.

GO Terms/Functions	DEGs (Counts)	P-Value	Associated KGs
Downregulated DEGs
GO Terms of Biological Processes (BPs)
GO:0060337~type I interferon signaling pathway [46]	12	8.41E-13	OAS1, OAS3, IRF9
GO:0051607~defense response to virus [47]	12	2.72E-08	OAS1, OAS3, IRF9
GO:0060333~interferon-gamma-mediated signaling pathway [47]	6	1.53E-04	OAS1,OAS3, IRF9, ATF6B
GO:0045071~negative regulation of viral genome replication [48]	5	1.86E-04	OAS1, OAS3
GO:0055114~oxidation-reduction process [49]	9	0.06191	NQO1, HPGD, AKR1C1
GO Terms of Cellular Components (CCs)
GO:0005737~cytoplasm [50]	57	4.91E-05	OAS1, OAS3, IRF9, HPGD, TP53INP1, NQO1
GO:0005578~proteinaceous extracellular matrix [8]	7	0.009721	FN1
GO Terms of Molecular Function (MF)
GO:0016491~oxidoreductase activity [51]	5	0.032918	HPGD, AKR1C1
Upregulated DEGs
GO Terms of BP
GO:0045944~positive regulation of transcription from RNA polymerase II promoter [52]	7	0.014821	BCL11A, SLCO2A1
GO:0000122~negative regulation of transcription from RNA polymerase II promoter [53]	6	0.015973	BCL11A, NT5E
GO Terms of CC
GO:0072559~NLRP3 inflammasome complex [54]	2	0.017428	FN1
GO Terms of MF
GO:0097153~cysteine-type endopeptidase activity involved in apoptotic process [55]	2	0.02663	FN1
KEGG pathways	DEGs (Counts)	P-Value	Associated KGs
Downregulated DEGs
hsa05168:Herpes simplex infection [56]	6	0.012895	OAS1, OAS3, ATF6B, IRF9
Upregulated DEGs
hsa04151:PI3K-Akt signaling pathway [57]	4	0.030138	ANGPT1, SLCO2A1, BCL11A