Table 2. Biological and demographic characteristics of patients according to liver stiffness.
| Variables | LSM ≥ 8 kPa N = 10 | LSM < 8 kPa N = 179 | P |
|---|---|---|---|
| Age, years | 63.7 ± 3.6 | 60.4 ± 7.4 | 0.23 |
| Men, n (%) | 9 (90) | 144 (80.4) | 0.74 |
| BMI, kg/m 2 | 29.4 ± 5.8 | 27.5 ± 4.2 | 0.15 |
| BMI ≥ 30 kg/m2, n (%) | 4 (40) | 43 (24.0) | 0.45 |
| BMI ≥ 25 kg/m2, n (%) | 9 (90) | 126 (70.4) | 0.32 |
| Smokers, n (%) | 5 (50) | 121 (67.6) | 0.42 |
| Diabetes, n (%) | 5 (50) | 49 (27.4) | 0.23 |
| Arterial hypertension, n (%) | 7 (70) | 132 (73.7) | 0.73 |
| Dyslipidemia, n (%) | 9 (90) | 161 (89.9) | 1.00 |
| Metabolic syndrome, n (%) | 8 (80) | 93 (54.7) | 0.19 |
| Patients at “high-risk” of NAFLD†, n (%) | 8 (80) | 96 (53.9) | 0.19 |
| Patients “at risk” of NAFLD‡, n (%) | 10 (100) | 139 (78.1) | 0.21 |
| Alcohol consumption, g/jr | 0 [0–30] | 0 [0–10] | 0.61 |
| Excessive drinker, n (%) | 1 (10) | 11 (5.9) | 0.50 |
| Glycosylated hemoglobin, % | 6.6 ± 1.0 | 6.28 ± 0.97 | 0.22 |
| HDL cholesterol, mmol/L | 0.85 ± 0.27 | 1.05 ± 0.27 | 0.01 |
| LDL cholesterol, mmol/L | 2.1 ± 0.9 | 2.24 ± 0.91 | 0.61 |
| Total cholesterol, mmol/L | 3.6 ± 1.2 | 3.7 ± 1.2 | 0.55 |
| Triglycerides, mmol/L | 1.71 ± 0.86 | 1.48 ± 0.82 | 0.28 |
| Aspartate aminotransferase, IU/L | 27.5 [22.2–57.5] | 26 [22–30.2] | 0.062 |
| Alanine aminotransferase, IU/L | 48.5 [22.7–97] | 27 [19–36] | 0.050 |
| Gamma-glutamyl transferase, IU/L | 53 [26–132] | 30 [22–48] | 0.074 |
| Alkaline phosphatase, IU/L | 56 [40–84.7] | 72 [58–89] | 0.10 |
| Total bilirubin, μmol/L | 12 ± 3.4 | 13.1 ± 6.9 | 0.94 |
| Albumin, g/L | 36.4 ± 2.8 | 36.0 ± 2.8 | 0.56 |
| Platelets, G/L | 226 ± 43 | 258 ± 73 | 0.20 |
| Prothrombin index or Factor V, % | 89.3 ± 11.7 | 96.2 ± 11.6 | 0.09 |
| Creatinine, μmol/L | 89.3 ± 24.4 | 83.6 ± 23.4 | 0.34 |
| C-reactive protein, mg/L | 2 [0.57–4.57] | 1.3 [0.7–2.9] | 0.59 |
| CAP ≥ 275 dB/m, n (%) | 4 (40) | 83 (46.9) | 0.92 |
| Fibroscan, kPa | 10.0 ± 1.9 | 5.0 ± 1.3 | <0.0001 |
Quantitative data are expressed as mean ± standard deviation (SD) or median [interquartiles; IQR].
†: Patients with at least one of the following conditions: elevated ALT, diabetes, triglycerides ≥ 1.7 mmol/L, BMI ≥ 30 kg/m2.
‡: Patients with at least one of the following conditions: elevated ALT, diabetes, triglycerides ≥ 1.7 mmol/L, BMI ≥ 25 kg/m2.
BMI, body mass index; CAP, controlled attenuation parameter; HDL, high-density lipoprotein; LDL, low-density lipoprotein; LSM, Liver stiffness measurement.