Table 1.
Summary of catabolic factors regulating the metabolic reprogramming in adipose tissue.
| Secreted factor | Source | Name | Metabolic role in adipose tissue |
|---|---|---|---|
| Yes | Tumor | PTHrP | Browning |
| Lipolysis | |||
| Tumor | GDF15 | Lipolysis | |
| Browning | |||
| Tumor | ZAG | Lipolysis | |
| Adipocyte | Browning | ||
| Tumor | LIF | Lipolysis | |
| Tumor | Adrenomedullin | Lipolysis | |
| Adipocyte | |||
| Tumor | TNF-α | Lipolysis | |
| Immune cells | |||
| Inflammation | |||
| Adipocyte | |||
| Tumor | IL-6 | Lipolysis | |
| Immune cells | Browning | ||
| Adipocyte | Inflammation | ||
| Adipocyte | Leptin | Lipolysis | |
| Sympathetic neurons | Catecholamines | Browning | |
| Lipolysis | |||
| Brain | Natriuretic peptides | Lipolysis | |
| Heart | |||
| Adrenal gland | Glucocorticoids | Lipolysis | |
| Pancreas | Insulin | Lipogenesis | |
| No | Adipocyte | CIDEA | Lipolysis |
| HSL | Lipolysis | ||
| ATGL | Lipolysis | ||
| LPL | Lipogenesis | ||
| FAS | Lipogenesis | ||
| TLR4 signaling | Lipolysis | ||
| Browning | |||
| Immune cell composition |