Table 2.

Serum cytokine levels of healthy controls, MBL subjects and CLL patients.

Cytokine	Control (n=24)		MBL (n=40)		CLL (n=44)		P-value
	Median	Range	Median	Range	Median	Range	MBL vs. Control	CLL vs. Control	CLL vs. MBL
IL1β	0.26	0.07–5.85	0.35	0.07–124.27	0.47	0.07–114.13	0.475	0.061	0.219
IL2	1.49	0.44–8.07	1.49	0.44–11.80	1.66	0.44–16.49	0.633	0.273	0.483
IL4	0.21	0.06–0.79	0.21	0.06–40.67	0.08	0.06–1.34	0.875	0.270	0.210
IL5	1.44	0.45–4.97	2.01	0.52–4.42	1.51	0.45–4.19	0.004	0.558	0.005
IL6	2.04	1.16–151.09	3.62	1.16–1431.63	2.80	0.34–1689.05	0.021	0.080	0.495
IL8	22.05	6.15–5216.03	238.01	7.21–6810.22	20.73	4.00–8807.27	0.005	0.980	0.019
IL10	0.74	0.39–1.66	0.93	0.39–3.74	0.88	0.39–5.03	0.017	0.179	0.451
IL12	1.07	0.60–3.57	1.07	0.60–18.42	1.07	0.60–3.08	0.299	0.358	0.824
IL15	3.21	1.03–7.65	2.92	0.51–7.09	2.88	0.51–7.92	0.787	0.787	0.865
IL17A	2.51	0.51–13.14	2.52	0.51–21.39	2.52	0.51–16.69	0.199	0.196	0.895
IFNα	1.23	0.45–6.58	1.98	0.45–7.95	2.20	0.45–14.91	0.286	0.306	0.913
IFNγ	11.24	3.30–42.08	16.69	1.44–151.14	13.24	3.30–69.33	0.014	0.577	0.026
TNFα	2.25	0.50–29.74	4.99	1.30–69.19	3.30	0.70–28.21	0.015	0.140	0.149
GM-CSF	0.23	0.09–1.05	0.42	0.09–1.51	0.24	0.09–0.88	0.151	0.305	0.590
CCL3	22.67	17.80–2925.30	46.00	19.05–2913.37	39.13	4.61–6427.70	0.001	0.070	0.395
CCL4	114.53	56.66–1753.44	176.57	76.92–2358.09	151.61	29.75–2915.75	0.012	0.114	0.275
CCL19	109.36	52.26–449.53	131.95	3.17–871.66	108.35	4.53–1561.50	0.071	0.908	0.078
CXCL9	70.98	15.70–1044.45	165.53	15.70–1166.00	151.78	15.70–1982.50	0.003	0.001	0.964
CXCL10	188.10	102.88–985.02	325.21	10.73–1904.78	230.79	5.25–735.04	0.016	0.581	0.029
CXCL11	32.37	13.15–122.40	47.05	10.60–213.10	53.69	8.09–315.39	0.010	0.038	0.844

All determinations were performed in duplicate. Cytokine values are reported in picograms per milliliter (pg/ml). Significant P-values (<0.05) are highlighted in bold.