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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Biochem Pharmacol. 2021 Jul 23;193:114698. doi: 10.1016/j.bcp.2021.114698

Fig. 1.

Fig. 1.

The effect of HFD on obesity phenotypes in male and female WT and PXR-KO mice. (A). Body weights of male mice (B). Body weights of female mice (C). Weight gain. Data represent mean ± SEM (n = 7–11). Hepatic gene expression of (D). pregnane X receptor (Pxr) (E). Cyp2b19 (F). Cyp2b10, (G). Collage 1α, and Gapdh mRNAs were quantified as described in Materials and Methods. Data represent mean ± SEM (n = 5–6). #P < 0.05 between mice fed control and high-fat diet (HFD). †P < 0.05 between male mice fed HFD. βP < 0.05 between male and female mice fed HFD. §P < 0.05 between female mice fed HFD.