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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Biochem Pharmacol. 2021 Jul 23;193:114698. doi: 10.1016/j.bcp.2021.114698

Fig. 15.

Fig. 15.

Pearson correlations between PXR-dependent liver genes (liver microarray) or hepatic bile acids (UPLC-MS/MS) and gut microbiota/microbial metabolites (16S rDNA sequencing/LC-MS) following HFD ingestion. (A-B). Pearson correlation of differentially regulated intestinal bacteria and PXR-dependent HFD-regulated liver genes in the following category: xenobiotic biotransformation & bile acid metabolism, energy metabolism, as well as inflammation (C-D). Pearson correlations of liver bile acids and differentially regulated intestinal bacteria of male and female WT and PXR-KO mice as regulated by HFD.