Table 1.

Body weight and food intake of adult (8–10 weeks) male and female wild type (WT, C57BL/6J) and PXR-KO mice and after 16 weeks on a control or a high-fat diet (HFD).

Parameter	Male WT Control (n = 7)	HFD (n = 9)	Female WT Control (n = 7)	HFD (n = 8)	Male PXR-KO Control (n = 11)	HFD (n = 12)	Female PXR-KO Control (n = 11)	HFD (n = 11)
Initial weight (g)	24.6 ± 0.8	24.8 ± 0.9	20.0 ± 0.5‡	20.4 ± 0.5	23.9 ± 0.5	23.6 ± 0.5	19.9 ± 0.6‡	20.0 ± 0.5
Final weight (g)	35.9 ± 1.4	50.5 ± 0.7#	27.0 ± 1.1	44.3 ± 1.8#	31.4 ± 0.9	39.1 ± 1.5#,†	25.3 ± 0.5	32.4 ± 1.9#,§
Absolute liver weight (g)	1.5 ± 0.1	2.7 ± 0.2#	1.2 ± 0.1	1.5 ± 0.1β	1.6 ± 0.1	1.9 ± 0.2†	1.4 ± 0.1	1.3 ± 0.1β
Liver/body weight (%)	4.1 ± 0.1	5.4 ± 0.4#	4.4 ± 0.2	3.3 ± 0.2 β	5.0 ± 0.1	4.9 ± 0.3	5.6 ± 0.2	4.1 ± 0.1#
Epididymal WAT mass (g)	2.0 ± 0.2	1.7 ± 0.1	0.9 ± 0.2	3.3 ± 0.2#, β	1.1 ± 0.1	1.8 ± 0.1	0.8 ± 0.1	2.2 ± 0.3#,§
Mesenteric WAT mass (g)	0.5 ± 0.04	1.1 ± 0.11#	0.4 ± 0.05	1.3 ± 0.16#	0.4 ± 0.05	0.9 ± 0.11#	0.3 ± 0.03	0.6 ± 0.10§
BAT (g)	0.4 ± 0.02	0.6 ± 0.04#	0.2 ± 0.01	0.5 ± 0.05#	0.3 ± 0.03	0.4 ± 0.04†	0.3 ± 0.02	0.3 ± 0.04,§
1Lean Mass at 3 months (g)	25 ± 0.3	27 ± 1.3	19 ± 0.7‡	21 ± 0.7β	24 ± 0.3	23 ± 0.3†	21 ± 0.4	21 ± 0.5
1Fat Mass at 3 months (g)	4 ± 0.6	13 ± 1.9#	3 ± 0.1	9 ± 0.8#, β	4 ± 0.4	8 ± 0.3†	3.3 ± 0.7	7 ± 0.7
Food Intake (g/day)	3.1 ± 0.04	6.2 ± 0.62#	2.5 ± 0.07	6.5 ± 0.05#	2.9 ± 0.01	5.4 ± 0.29#	2.7 ± 0.04	5.1 ± 0.23#,§

Data represent mean ± SEM for 7–11 mice per group.

^‡P < 0.05 between male and female mice fed the control diet.

^#P < 0.05 between mice fed control diets and high-fat diet (HFD).

^†P < 0.05 between male mice fed HFD.

^§P < 0.05 between female mice fed HFD.

^βP < 0.05 between male and female mice fed a HFD.

¹For body mass composition, n = 3–4 and were performed after 3 month of diet administration