Table 2.

Serum parameters of adult male and female wild type (WT, C57BL/6J) and Pxr-null mice and after 16 weeks on a control or a high-fat diet (HFD).

Serum Parameter	Male WT Control (n = 7)	HFD (n = 9)	Female WT Control (n = 7)	HFD (n = 8)	Male PXR-KO Control (n = 11)	HFD (n = 12)	Female PXR-KO Control (n = 11)	HFD (n = 11)
ALT (IU/L)	27.1 ± 4.8	82.6 ± 9.0#	21.7 ± 4.1	35.1 ± 11.5β	27.7 ± 2.6	22.6 ± 4.7†	24.7 ± 5.8	36.4 ± 17.5
Bile Acids (μmole/L)	37.3 ± 2.4	62.1 ± 4.2#	32.2 ± 2.0	33.5 ± 3.7β	35.6 ± 1.7	42.1 ± 7.0†	34.8 ± 3.7	35.6 ± 4.0
FGF21 (pg/mL)	764 ± 84	1343 ± 187#	275 ± 85	614 ± 125 β	225 ± 74	356 ± 69†	337 ± 92	453 ± 86
Adiponectin (ng/mL)	11.1 ± 0.7	9.4 ± 0.4	17.0 ± 0.4‡	18.3 ± 0.7β	7.7 ± 0.7	7.4 ± 0.6	16.2 ± 1.8‡	16.0 ± 0.8β
Insulin (pg/mL)	2.4 ± 0.7	19.5 ± 2.1#	1.7 ± 0.6	2.3 ± 0.8β	0.9 ± 0.4	14.4 ± 5.5#	0.7 ± 0.1	1.1 ± 0.2β
Leptin (ng/mL)	31.2 ± 3.0	48.1 ± 2.2#	18.1 ± 2.5	51.6 ± 4.8#	12.9 ± 3.1*	35.4 ± 4.0#	16.4 ± 3.1	38.7 ± 4.4#
Fasting glucose (mg/dL)	133 ± 15	170 ± 11	117 ± 11	137 ± 8	119 ± 12	191 ± 11#	108 ± 10	130 ± 6β

Data represent mean ± SEM for 7–11 mice per group.

^§P < 0.05 between female mice fed HFD.

¹For body mass composition, n = 3–4 and were performed after 3 month of diet administration

^‡P < 0.05 between male and female mice fed the control diet.

^#P < 0.05 between mice fed control diets and high-fat diet (HFD).

^†P < 0.05 between male mice fed HFD.

^βP < 0.05 between male and female mice fed a HFD.