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. 2022 May 16;18(5):e1009973. doi: 10.1371/journal.pgen.1009973

Fig 6. Allele-dependent chromatin accessibility at AD risk loci.

Fig 6

(A) AD-associated genetic risk variants with allele-dependent ATAC-seq peaks in CD4+ T cells. Each variant is heterozygous and located within an ATAC-seq peak in the indicated individual, facilitating measurement of allelic ratios informatics operator (MARIO) analysis to identify allele-dependent behavior. Red tick marks indicate allelic accessibility in a subject who with AD. Complete data are presented in S12 Table. All results shown have MARIO allelic reproducibility score (ARS) values ≥ 0.4, and hence, are allele-dependent. In the cutout, the participant identifier and reads under the ATAC-seq peak overlapping rs10791824 mapping to the strong and weak bases are provided.