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. 2022 May 16;11:e75526. doi: 10.7554/eLife.75526

Figure 2. Enrichment of partners of aneuploid proteins in differentially abundant proteins on other chromosomes.

(A) Standard residuals and p-values for the overlap between co-complex members of differentially abundant proteins on aneuploid chromosomes and differentially abundant proteins on other chromosomes for 13 amplifications and 20 deletions. (B) Protein abundance correlations between differentially abundant proteins on aneuploid chromosomes and their co-complex and non-complex subunits. Correlations were calculated across cancer samples, separately for each cancer type, and then pooled. Wilcoxon test was used to determine whether two distributions are significantly different. (C) The number of protein-protein interactions (PPIs; n=701) between differentially abundant proteins of aneuploid chromosomes and those on other chromosomes against the background distribution for COREAD chromosome 7 amplification. (D) Standard residuals and p-values for the overlap between CORUM complex subunits and differentially abundant proteins on other chromosomes for 13 amplifications and 20 deletions.

Figure 2.

Figure 2—figure supplement 1. Transcriptome-level changes on other chromosomes.

Figure 2—figure supplement 1.

Standard residuals and adjusted p-values for the overlap between (A) co-complex members of differentially expressed genes on aneuploid chromosomes and differentially expressed genes on other chromosomes, for 203 detected cancer-type-specific aneuploidies; 86 amplifications and 117 deletions, and (B) CORUM complex subunits and differentially expressed genes on other chromosomes.