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Predicted and observed values of the optimaized MRT loaded into SBA-15.
| Factor (independent variables) | Optimized level | ||
|---|---|---|---|
| A: drug/MSNs (%) | 33.33% | ||
| B: type of MSN's | SBA-15 | ||
| C: loading method | Incipient wetness | ||
| Responses (dependent variables) | Expected | Observed | Residual* |
| Y1: loading efficiency (%) | 102.03 | 104.05 | − 2.02 |
| Y2: aqueous solubility (mg/ml) | 0.188 | 0.200 | − 0.012 |
| Y3: release after 30 min (%) | 91.02 | 100 | −8.98 |
* Residual: expected-observed.
