Table 1.
The inhibitory effect of DiMC alone (I) and DOX-DiMC combination (II) against in vitro proliferation of MCF-7 cells (n = 3).
| Final concentration of DiMC (ng/mL) | Mean inhibition rate/% |
Q valueb | |
|---|---|---|---|
| I | IIa | ||
| 24 | 23.1 | 53.8 | 0.886 |
| 48 | 28.3 | 57.5 | 0.907 |
| 96 | 40.4 | 68.1 | 0.979 |
| 144 | 48.9 | 86.5 | 1.171 |
| 192 | 58.2 | 88.3 | 1.123 |
aThe final DOX concentration was 24 ng/mL for each combination.
bThe Q value was calculated according to the following equation as E(DOX-DiMC)/(EDOX+EDiMC－EDOX×EDiMC), where EDOX and EDiMC meant the inhibition rate caused by DOX or DiMC alone, and E(DOX-DiMC) was that of DOX-DiMC combination at the corresponding concentration.