Table 2. Time-to-achievement of ITI success according to responder type and prior ITI.
| ITI success criteria | Patients | Median (IQR) time to achievement of criteria, months | ||
|---|---|---|---|---|
| Low responders | High responders | All | ||
| FVIII inhibitor titer < 0.6 BU/mL ( n = 71) | All patients | 0.82 (0.30–7.23) | 4.17 (2.14–8.97) | 4.01 (1.61–8.97) |
| Primary ITI | 2.84 (0.26–7.23) | 4.01 (2.14–8.97) | 4.01 (1.61–8.97) | |
| Rescue ITI | 0.82 (0.72–12.65) | 5.72 (2.53–7.16) | 4.80 (1.30–9.45) | |
| FVIII recovery ≥ 66% ( n = 72) |
All patients | 2.50 (0.69–3.94) | 8.97 (3.42–15.57) | 5.82 (2.92–13.75) |
| Primary ITI | 2.53 (0.69–3.94) | 9.03 (3.45–16.59) | 6.36 (2.92–15.36) | |
| Rescue ITI | 0.72 (0.13–7.23) | 5.32 (3.22–10.84) | 5.29 (1.95–10.84) | |
| FVIII half-life ≥ 6 hours ( n = 62) |
All patients | 6.47 (4.93–12.35) | 10.87 (5.98–20.53) | 10.12 (5.75–16.79) |
| Primary ITI | 6.24 (2.33–16.79) | 11.40 (5.98–21.62) | 8.15 (5.49–21.19) | |
| Rescue ITI | 12.29 (9.40–12.35) | 10.86 (5.68–13.54) | 10.87 (8.18–12.35) | |
| Partial success ( n = 70) |
All patients | 2.33 (0.69–6.11) | 7.13 (3.68–15.57) | 5.55 (3.19–12.48) |
| Primary ITI | 2.41 (0.26–6.11) | 7.44 (3.68–16.59) | 5.75 (3.15–15.36) | |
| Rescue ITI | 0.82 (0.72–9.40) | 5.72 (3.22–11.73) | 5.49 (3.19–10.84) | |
| Complete success ( n = 60) |
All patients | 11.91 (6.42–16.92) | 10.96 (6.67–18.56) | 11.25 (6.52–18.56) |
| Primary ITI | 10.09 (6.37–21.19) | 11.25 (6.49–24.87) | 11.04 (6.41–21.62) | |
| Rescue ITI | 12.35 (12.29–12.65) | 10.86 (7.47–13.54) | 12.19 (8.18–12.65) | |
Abbreviations: FVIII, factor VIII; IQR, interquartile range; ITI, immune tolerance induction.