On-chip plasma separation methods including active (a-c) and passive (d, e) methods: (a) Centrifugal separation in a CD-shaped disk. (b) Acoustic microstreaming vortex to trap blood cells. (c) Dielectrophoresis-induced plasma separation. (d) Silicon-based microfilter including (i) weir-type filter, (ii) pillar-type filter, (iii) cross-flow filter, and (iv) membrane filter. (e) Dual separation by combination of sedimentation and membrane filtration. Reproduced with permission from (a) ref. 226, copyright 2006, The Royal Society of Chemistry; (b) ref. 227, copyright 2021, Elsevier; (c) ref. 228, copyright 2015, Springer Nature; (d) ref. 229, copyright 2008, Springer Nature; (e) ref. 238, copyright 2013, American Chemical Society.