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. Author manuscript; available in PMC: 2023 Jan 4.
Published in final edited form as: Chem Soc Rev. 2022 Jan 4;51(1):329–375. doi: 10.1039/c9cs00621d

Figure 16.

Figure 16.

A typical structure of active optofluidic device for protein detection. (a) SERS-based microdroplet device for detection of prostate-specific antigen (PSA) cancer markers. It has 5 compartments with different functions: (i) generating microdroplet and mixing reagents; (ii) forming immunocomplexes on magnetic beads; (iii) separating immunocomplexes by magnetic bar; (iv) moving the supernatant that contained the unbound SERS probes; and (v) separating magnetic immunocomplexes through droplet splitting. (b) In vitro fluorescence microfluidic device for multiplexed detection of proteins in finger-prick whole blood. Reproduced with permission from (a) ref. 218, copyright 2016, The Royal Society of Chemistry; (b) ref. 235, copyright 2008, Springer Nature.