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. 2022 Mar 21;18(6):596–604. doi: 10.1038/s41589-022-00985-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, The SI/II BRET probe is used to quantify binding of unmodified SII-P ligands to RAS in live cells. Image created with BioRender.com from PDB 6OIM (AMG510-KRAS(G12C)). b, Protracted KRAS(G12C) engagement is observed for AMG510 (1). Data are representative of two independent experiments (n = 2), and individual data points are the mean ± s.d. of four technical replicates. c, Comparison of BRET target engagement data after 2 h at KRAS(G12C) versus p-ERK from MIA PaCa-2 cells as reported⁵. Data are means of four independent experiments ± s.e.m. (n = 4).

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