Table 1. Clinical characteristics and lipid profiles of our patients.
| Variable | All patients | Pathogenic variants in the FH causative genes | P value | |
|---|---|---|---|---|
|
Patients: 33 Families: 29 |
Positive group Patients: 16 Famillies: 14 |
Negative group Patients: 17 Famillies: 15 |
||
| Age (years) | 9.7±4.2 | 9.5±3.9 | 9.9±4.4 | n.s. |
| Sex Boys (%) | 10 (30.3) | 5 (31.3) | 5 (29.4) | n.s. |
| Ht-SDS | -0.3±1.1 | -0.6±0.9 | -0.1±1.2 | n.s. |
| POW (%) | 3.3±14.9 | 1.1±11.6 | 5.3±17.1 | n.s. |
| BMI% | 50.5±27.0 | 47.7±23.4 | 52.9±29.6 | n.s. |
| Total cholesterol (mg/dL) | 263±42 | 280±36 | 246±40 | ＜0.05 |
| LDL-C (mg/dL) | 196±44 | 217±38 | 177±42 | ＜0.01 |
| non-HDL-C (mg/dL) | 208±45 | 228±39 | 188±42 | ＜0.01 |
| HDL-C (mg/dL) | 55±10 | 53±9 | 57±10 | n.s. |
| Triglyceride (mg/dL) | 103±49 | 105±51 | 102±48 | n.s. |
| Tendon xanthomata (%) | 0 (0) | 0 (0) | 0 (0) | - |
| Family history of premature CAD patients/families (%) | 3/3 (9.1/10.3) | 2/2 (12.5/14.3) | 1/1 (5.9/6.7) | n.s. |
Values are n (percentage) or means±SD. The P value; variant-positive group vs variant-negative group. Ht-SDS, height standard deviation score; POW, percentage of overweight; BMI%, BMI-for-age percentile; CAD, coronary artery disease. n.s., not significant.