Table 3. Measurements stratified by sdLDL-cholesterol quartile in subjects with diabetes.
| Quartile | Q1 | Q2 | Q3 | Q4 | p trend＊1 |
|---|---|---|---|---|---|
| sdLDL-C (mg/dl) | 17.5 (8.5-21.3) | 24.6 (21.4-28.0) | 32.4 (28.1-38.0) | 48.7 (38.1-117.6) | |
| Number | 276 | 270 | 268 | 271 | |
| Male | 166 (60%) | 151 (56%) | 174 (65%) | 189 (70%) | 0.0041 |
| Age | 68 (11) | 67 (11) | 68 (11) | 65 (12) | 0.0114 |
| Current smoker | 46 (17%) | 38 (14%) | 42 (16%) | 57 (21%) | ns |
| Alcohol drinker | 86 (31%) | 82 (30%) | 91 (34%) | 123 (45%) | 0.0004 |
| Coronary heart disease | 43 (16%) | 30 (11%) | 23 (9%) | 21 (8%) | 0.0019 |
| Cerebelovascular disease | 26 (9%) | 24 (9%) | 22 (8%) | 19 (7%) | ns |
| Type 1 diabetes | 13 (5%) | 7 (3%) | 5 (2%) | 2 (1%) | 0.0027 |
| Insuilin | 71 (26%) | 61 (23%) | 57 (21%) | 43 (16%) | 0.0054 |
| insulin dose | 20 [14-30] | 24 [16-33] | 21 [11-31] | 28 [20-40] | ns |
| Hypelipidemic agents | 177 (64%) | 171 (63%) | 170 (63%) | 163 (60%) | ns |
| Statins | 162 (59%) | 150 (56%) | 153 (57%) | 132 (49%) | 0.0347 |
| Fibrates | 13 (5%) | 18 (7%) | 14 (5%) | 30 (11%) | 0.0102 |
| Hypotensive agents | 166 (60%) | 160 (59%) | 154 (57%) | 165 (61%) | ns |
| SBP (mmHg) | 130 (15) | 131 (13) | 132 (14) | 133 (14) | 0.0452 |
| BMI (Kg/m2) | 24.3 (4.3) | 25.2 (4.3) | 25.1 (3.7) | 26.2 (4.3) | ＜0.0001 |
| Fatty liver＊2 | 17 (25%) | 27 (50%) | 39 (58%) | 47 (61%) | ＜0.0001 |
| VFA (cm2)＊3 | 105 (59) | 157 (71) | 170 (77) | 203 (82) | ＜0.0001 |
| ALT (U) | 16 [13-23] | 20 [15-29] | 21 [16-30] | 26 [17-39] | ＜0.0001 |
| γGTP (U) | 19 [14-28] | 24 [16-37] | 25 (18-38) | 37 (22-66) | ＜0.0001 |
| HbA1c (%) | 7.3 (0.8) | 7.3 (0.8) | 7.4 (0.9) | 7.5 (1.0) | ns |
| Glucose (mg/dL) | 141 (40) | 149 (35) | 150 (37) | 157 (44) | ＜0.0001 |
| C-peptide (mg/dL) | 1.0 [0.7-1.6] | 1.2 [0.8-1.8] | 1.3 [0.9-1.9] | 1.6 [1.1-2.2] | ＜0.0001 |
| TC (mg/dL) | 159 (24) | 180 (26) | 186 (27) | 202 (30) | ＜0.0001 |
| TG (mg/dL) | 73 [57-96] | 93 [71-121] | 115 [91-151] | 166 [120-227] | ＜0.0001 |
| LDL-C (mg/dL) | 83 (17) | 101 (19) | 107 (21) | 118 (24) | ＜0.0001 |
| LDL-TG (mg/dL) | 13.2 [10.6-16.0] | 14.2 [11.6-16.5] | 14.6 [12.3-17.0] | 16.6 [13.8-20.9] | ＜0.0001 |
| HDL-C (mg/dL) | 57 (15) | 57 (15) | 54 (14) | 50 (12) | ＜0.0001 |
| NonHDL-C (mg/dL) | 102 (18) | 123 (20) | 132 (21) | 152 (26) | ＜0.0001 |
| lbLDL-C (mg/dL) | 66 (16) | 76 (19) | 74 (21) | 66 (24) | ns |
| TRL-C (mg/dL) | 19 [15-23] | 22 [17-27] | 24 [19-30] | 32 [24-41] | ＜0.0001 |
| apoB (mg/dL) | 70 (10) | 83 (11) | 91 (12) | 106 (17) | ＜0.0001 |
| apoCIII (mg/dL) | 8.2 [6.9-9.9] | 9.6 [8.2-11.2] | 11.1 [9.3-13.0] | 13.8 [11.2-16.6] | ＜0.0001 |
| apoE (mg/dL) | 3.6 (1.1) | 3.9 (1.0) | 4.0 (1.1) | 4.9 (1.4) | ＜0.0001 |
| Lp (a) (mg/dL) | 14.3 [7.1-28.7] | 14.4 [6.6-26.4] | 11.8 [5.9-20.9] | 11.9 [5.6-24.0] | 0.0119 |
| eGFR (ml/min/1.73m2) | 70 (21) | 70 (18) | 72 (20) | 72 (21) | ns |
| UAR (mg/g) | 18.3 [6.6-54.3] | 13.7 [5.7-40.8] | 16.5 [7.3-45.9] | 19.3 [7.5-73.8] | ns |
| WBC | 6301 (1762) | 6419 (1682) | 6701 (993) | 6919 (1046) | ＜0.0001 |
| hsCRP (ng/L) | 0.05 [0.02-0.11] | 0.06 [0.03-0.14] | 0.05 [0.03-0.11] | 0.08 [0.04-0.17] | ＜0.0001 |