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. 2022 May 27;185(14):2434–2451.e17. doi: 10.1016/j.cell.2022.05.022

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Figure S2 — Representative gating strategy for T cell analysis. Related to Figure 3, Figure 4, Figure 5

(A) Representative strategies to define CD3⁺CD4⁺ and CD3⁺CD8⁺ cells by AIM and ICS assays.

(B-C) Representative gating strategy of spike-specific AIM⁺ CD4⁺ T cells induced by mRNA-1273, BNT162b2, Ad26.COV2.S, and NVX-CoV2373 COVID-19 vaccine platforms. Spike-specific CD4⁺ T cells were measured by Activation-Induced Makers (AIM) assay: AIM⁺ OX40⁺ and CD137⁺ (B) and AIM⁺ OX40⁺ and surface CD40L⁺ (C).

(D) Representative gating strategy of spike-specific circulating follicular helper T cells (cT_FH) induced by mRNA-1273, BNT162b2, Ad26.COV2.S, and NVX-CoV2373 COVID-19 vaccine platforms.

mRNA-1273 (red), BNT162b2 (blue), Ad26.COV2.S (green), and NVX-CoV2373 (purple).