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. 2022 May 26;12:8912. doi: 10.1038/s41598-022-12899-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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DNA methylation and mRNA expression statuses of SATB2 and NRG1 genes. (a,b) The DNA methylation levels of SATB2 (a) and NRG1 (b) genes are shown in dot plots. The vertical axis indicates the DNA methylation levels in the MED12m-positive uterine fibroids (n = 9), -negative uterine fibroids (n = 12), and the corresponding myometrium. The DNA methylation levels were examined by COBRA and range from 0 to 100%. (c,d) The expression levels of SATB2 (c) and NRG1 (d) genes in the MED12m-positive uterine fibroids, -negative uterine fibroids, and the myometrium analyzed by qRT-PCR are shown in dot plots. The expression levels are corrected for myometrium expression as 1. ^ap < 0.01 (higher expression in uterine fibroids compared to myometrium, student t-test). ^bp < 0.01 (lower expression in uterine fibroids compared to myometrium, student t-test).