Table 2.

Activated signalings of cell proliferation and anti-apoptosis in differentially expressed genes in uterine fibroids.

IPA pathway (p < 0.05)	MED12m-positive	MED12m-negative
Cell proliferation
Wnt/β-catenin signaling	●
HIF1α- signaling	●
mTOR signaling	●	●
PI3K/AKT signaling	●	●
p70S6K signaling	●	●
STAT3 siganling	●	●
RANK signaling in osteoclasts	●
PPARα/RXTα activation	●
NF-κB signaling	●
RAR activation	●	●
PXR/RXR activation		●
HER-2/ErbB signaling		●
ERK/MAPK siganling		●
LPS-stimulated MAPK signaling		●
Anti-apoptosis
14–3-3mediated signaling	●
PI3K/AKT signaling	●	●
p70S6K signaling	●	●
PAK signaling		●
IGF-1 signaling		●

Differentially expressed genes compared to the myometrium (the DEGs) in the MED12m-positive and -negative uterine fibroids were applied to KEGG pathway analysis in IPA, respectively. Detected pathways with p < 0.05 were considered significant enrichment. Activated signaling pathways related to cell proliferation and anti-apoptosis were indicated. Differentially expressed genes compared to the myometrium (the DEGs) in the MED12m-positive and -negative uterine fibroids were applied to KEGG pathway analysis in IPA, respectively. Detected pathways with p < 0.05 were considered significant enrichment. Activated signaling pathways related to cell proliferation and anti-apoptosis were indicated.