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. 2022 May 27;185(13):2279–2291.e17. doi: 10.1016/j.cell.2022.05.019

Figure 2.

Figure 2

Structural conservation of CCoV-HuPn-2018 S domain 0 and domain A

(A–C) Ribbon diagrams of the CCoV-HuPn-2018 S domain 0 (A) and domain A (B) oriented as shown in the prefusion S conformation in (C). Rendering in (C) uses a composite model obtained from the global and local refinements.

(D) Sequence alignment of CCoV-HuPn-2018 S domain A and domain 0 highlighting the low sequence identity (12.5%) between them.

(E–G) Topology diagrams of domain 0 (E) and domain A (F) and structural overlay between the two domains (G) underscoring their similarity.

N-linked glycans are rendered as blue spheres in (A)–(C) but were removed from (G) for clarity.

See also Figures S1 and S2 and Tables S1 and S2.