. 2021 Jun 29;16(3):507–516. doi: 10.1007/s11701-021-01267-8

Table 3.

Associations of physical, cancer and perioperative factors with the risk of positive surgical margins (PSM) in 1114 prostate cancer patients treated with robot assisted radical prostatectomy (RARP)

	NSM	PSM	PSM vs NSM		PSM vs NSM
	Statistics		Univariate analysis		Multivariate analysis
	Median (IQR) or frequency (%)	Median (IQR) or frequency (%)	OR (95% CI)	p value	OR (95% CI)	p value
N (%)	843 (75.7)	271 (24.3)
Physical factors
Blood group
A	376 (44.6)	91 (33.6)	Ref		Ref
B	99 (11.7)	28 (10.3)	1.169 (0.725–1.885)	0.523	1.175 (0.728–1.1898)	0.51
AB	43 (5.1)	10 (3.7)	0.961 (0.465–1.984)	0.914	0.922 (0.445–1.909)	0.83
O	325 (38.6)	142 (52.4)	1.805 (1.335–2.442)	< 0.0001	1.820 (1.344–2.464)	< 0.0001
Age	65 (61–70)	66 (61–71)	1.003 (0.982–1.024)	0.807
BMI	25.9 (24–28)	25.3 (23.1–28)	0.950 (0.909–0.993)	0.023	0.947 (0.905–0.990)	0.02
ASA I-II	760 (90.2)	249 (91.9)	Ref
ASA III	83 (9.8)	22 (8.1)	0.809 (0.495–1.322)	0.398
Cancer clinical factors
PSA	6.7 (5–9)	7.8 (5.4–12.2)	1.044 (1.021–1.067)	< 0.0001	1.042 (1.108–1.066)	0
PV	40 (31–53)	40 (30–50)	0.989 (0.981–0.998)	0.013	0.988 (0.979–0.996)	0.01
BPC	33 (21–50)	42 (28.3–63.5)	1.013 (1.007–1.019)	< 0.0001	1.009 (1.003–1.016)	0.01
ISUP < 3	607 (72)	185 (68.3)	Ref
ISUP > 2	236 (28)	86 (31.7)	1.196 (0.889–1.609)	0.238
cT < 2	528 (62.6)	159 (58.7)	Ref
cT > 1	315 (37.4)	112 (41.3)	1.181 (0.893–1.561)	0.243
cN0	802 (95.1)	256 (94.5)	Ref
cN1	41 (4.9)	15 (5.5)	1.146 (0.624–2.105)	0.660
Cancer specimen factors
PW	52 (43–65)	50 (41–62.5)	0.991 (0.984–0.999)	0.028	0.995 (0.985–1.004)	0.29
ISUP < 3	472 (56)	109 (40.2)	Ref		Ref
ISUP > 2	371 (44)	162 (59.8)	1.891 (1.432–2.498)	< 0.0001	1.678 (1.105–2.548)	0.02
pT2	704 (83.5)	170 (62.7)	Ref		Ref
pT3a	64 (7.6)	45 (16.6)	2.912 (1.920–4.416)	< 0.0001	2.259 (1.334–3.827)	0
pT3b	75 (8.9)	56 (20.7)	3.092 (2.105–4.542)	< 0.0001	2.072 (1.256–3.419)	0
pN0	456 (91.0)	143 (80.8)	Ref		Ref
pN1	45 (9.0)	34 (19.2)	2.409 (1.486–3.907)	< 0.0001	1.494 (0.859–2.5979	0.16
LN (n)	25 (20–32)	25 (21–31.5)	0.996 (0.979–1.013)	0.661
Perioperative factors
No PLND			Ref		Ref
PLND			1.302 (0.978–1.735)	0.071
HVS	477 (57.9)	123 (49.0)	Ref
LVS	347 (42.1)	128 (51)	1.431 (1.077–1.899)	0.013	1.290 (0.947–1.758)	0.11
OT	230 (200.5–255)	244 (215–273)	1.004 (1.001–1.006)	0.003	1.002 (0.999–1.005)	0.2
BL	250 (150–400)	300 (200–500)	1.001 (1.000–1.001)	0.009	1.001 (1.000–1.001)	0.01
CDS = 0	645 (76.5)	196 (72.3)	Ref
CDS > 0	198 (23.5)	75 (27.7)	1.247 (0.914–1.700)	0.164
LOHS	4 (4–5)	4 (4–5)	1.057 (0.990–1.130)	0.097
No RAD	816 (96.8)	263 (97.0)	Ref
RAD	27 (3.2)	8 (3.0)	0.919 (0.413–2.048)	0.837