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. 2021 Sep 30;44(2):699–717. doi: 10.1007/s11357-021-00466-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Cross-validation study of epigenetic clocks for vervet monkeys and humans. A–D Four epigenetic clocks that only apply to vervet. Leave-one-sample-out estimate of DNA methylation age (y-axis, in units of years) versus chronological age for A all available vervet tissues, B vervet blood, C vervet cerebral cortex, D vervet liver. Tenfold cross-validation analysis of the human-vervet monkey clocks for E, F chronological age and G, H relative age, respectively. E, G Human samples are colored in magenta and vervet samples are colored by vervet tissue type, and analogous in F, H but restricted to vervet samples (colored by vervet tissue type). Each panel reports the sample size (in parentheses), correlation coefficient, median absolute error (MAE)