Table 2.
Multivariable Cox models (unadjusted and adjusted) for all-cause mortality using the three phenotype categories (physical frailty, liver fibrosis, and liver frailty). The Salus in Apulia Study (n = 1929)
| HR | CI 95% | Std. Err | |
|---|---|---|---|
| Model 1 [C statistic:0.723 (std.err:0.019)] | |||
| Physical frailty | 1.47 | 0.98 to 2.16 | 0.20 |
| Age (years) | 1.11 | 1.09 to 1.14 | 0.01 |
| Sex (female) | 0.38 | 0.35 to 0.63 | 0.17 |
| Education (years) | 0.94 | 0.89 to 0.98 | 0.02 |
| Alcohol consumptiona | 0.22 | 0.05 to 0.89 | 0.71 |
| Model 2 [C statistics: 0.757 (std. err:0.018)] | |||
| FIB-4 (> 2.67) | 1.63 | 1.23 to 2.17 | 0.14 |
| Age (years) | 1.10 | 1.08 to 1.13 | 0.01 |
| Sex (female) | 0.49 | 0.37 to 0.66 | 0.14 |
| Education (years) | 0.97 | 0.93 to 1.01 | 0.02 |
| Alcohol consumptiona | 0.21 | 0.05 to 0.85 | 0.03 |
| Model 3 [C statistics: 0.732 (std. err.:0.019)] | |||
| Physical frailty | 1.63 | 0.96 to 2.77 | 0.27 |
| FIB-4 (> 2.67) | 1.70 | 1.18 to 2.45 | 0.18 |
| Liver frailty | 2.09 | 1.16 to 3.74 | 0.29 |
| Age (years) | 1.10 | 1.07 to 1.13 | 0.01 |
| Sex (female) | 0.41 | 0.29 to 0.58 | 0.17 |
| Education (years) | 0.94 | 0.90 to 0.99 | 0.02 |
| Alcohol consumptiona | 0.21 | 0.05 to 0.88 | 0.71 |
Model 1: Results of Cox multi-variable analysis on physical frailty as regressor, corrected for age, sex, education, and alcohol consumption. Model 2: Results of Cox multi-variable analysis on fibrosis-4 (FIB-4) score (> 2.67] as regressor, corrected for age, sex, education, and alcohol consumption. Model 3: Results of Cox multi-variable analysis on physical frailty, FIB-4 (> 2.67] and liver frailty as regressors, corrected for age, sex, education, and alcohol consumption
aAlcohol consumption Yes if > 50 g/day or 18,250 g/year (males), and > 25,g/day or 9125,g/year (females)