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. 2022 Feb 11;44(2):763–783. doi: 10.1007/s11357-022-00527-1

Table 2.

Fatty acid composition of total lipids from different human brain regions comparing middle-aged and elderly individuals. Healthy individuals were grouped as middle-aged (< 60 years) and elderly (> 60 years). Differences between groups were assessed by applying a t-test and corrected by FDR method of Benjamini and Hochberg, with Q = 10%. Values are reported in mol% as mean ± SEM from 8 to 9 individuals × group. P < 0.05 was selected as the minimum level of statistical significance. Significance compared to middle-aged group prior FDR correction is denoted using asterisks (*P < 0.05; **P < 0.01; ***P < 0.001)

HINDBRAIN MIDBRAIN
Olive Vermis Substantia nigra
Middle-aged Elderly Sig Middle-aged Elderly Sig Middle-aged Elderly Sig
14:0 1.84 ± 0.19 1.29 ± 0.12* 0.546 1.08 ± 0.05 0.99 ± 0.05 0.803 0.61 ± 0.02 0.65 ± 0.02 0.578
16:0 15.36 ± 0.26 15.78 ± 0.44 0.775 24.5 ± 0.56 24.7 ± 0.38 0.908 17.55 ± 0.18 18.28 ± 0.49 0.457
16:1n7 2.23 ± 0.09 2.11 ± 0.25 0.775 1.22 ± 0.08 1.14 ± 0.07 0.803 1.22 ± 0.03 1.35 ± 0.05* 0.229
18:0 20.11 ± 0.52 19.24 ± 0.81 0.597 20.28 ± 0.18 20.82 ± 0.48 0.803 22.57 ± 0.13 22.98 ± 0.29 0.571
18:1n9 30.57 ± 0.35 31.3 ± 2.48 0.597 20.81 ± 0.56 20.44 ± 0.84 0.813 24.1 ± 0.33 24.06 ± 1.00 0.947
18:1n7 5.19 ± 0.16 5.28 ± 0.17 0.917 4.37 ± 0.16 4.15 ± 0.13 0.803 5.08 ± 0.09 5.18 ± 0.19 0.805
18:2n6 0.62 ± 0.11 0.54 ± 0.09 0.775 0.94 ± 0.11 0.92 ± 0.07 0.944 0.73 ± 0.07 0.71 ± 0.061 0.879
18:3n3 0.18 ± 0.00 0.17 ± 0.01 0.775 0.07 ± 0.00 0.07 ± 0.00 0.803 0.11 ± 0.00 0.1 ± 0.00 0.571
18:4n3 0.05 ± 0.00 0.03 ± 0.00 0.597 0.03 ± 0.00 0.03 ± 0.00 0.803 0.02 ± 0.00 0.04 ± 0.00* 0.173
20:0 0.44 ± 0.09 0.38 ± 0.03 0.775 0.23 ± 0.00 0.28 ± 0.01** 0.068 0.24 ± 0.01 0.24 ± 0.00 0.947
20:1n9 4.54 ± 0.21 4.17 ± 0.68 0.775 1.40 ± 0.11 1.41 ± 0.14 0.946 2.31 ± 0.23 2.04 ± 0.15 0.578
20:2n6 0.86 ± 0.08 0.95 ± 0.12 0.774 0.29 ± 0.03 0.26 ± 0.01 0.803 0.45 ± 0.03 0.41 ± 0.04 0.658
20:3n6 1.53 ± 0.10 1.38 ± 0.11 0.753 1.02 ± 0.07 0.9 ± 0.06 0.803 1.42 ± 0.06 1.28 ± 0.12 0.571
20:4n6 4.3 ± 0.14 4.77 ± 0.73 0.565 8.02 ± 0.15 7.82 ± 0.28 0.803 6.95 ± 0.22 7.2 ± 0.23 0.607
20:5n3 0.05 ± 0.00 0.05 ± 0.01 0.981 0.05 ± 0.01 0.03 ± 0.01 0.803 0.14 ± 0.01 0.12 ± 0.01 0.571
22:0 0.4 ± 0.12 0.31 ± 0.04 0.775 0.07 ± 0.00 0.07 ± 0.00 0.944 0.13 ± 0.01 0.11 ± 0.01 0.578
22:1n9 0.83 ± 0.10 0.73 ± 0.79 0.775 0.85 ± 0.05 0.93 ± 0.06 0.803 0.96 ± 0.16 0.8 ± 0.34 0.616
22:4n6 3.78 ± 0.17 4.00 ± 0.22 0.774 2.96 ± 0.10 2.79 ± 0.26 0.803 4.67 ± 0.08 4.55 ± 0.18 0.689
22:5n6 0.24 ± 0.02 0.22 ± 0.13 0.775 0.75 ± 0.09 0.67 ± 0.12 0.813 0.46 ± 0.02 0.38 ± 0.12 0.457
22:5n3 0.20 ± 0.01 0.27 ± 0.02* 0.546 0.3 ± 0.019 0.27 ± 0.02 0.803 0.46 ± 0.02 0.45 ± 0.03 0.814
22:6n3 1.75 ± 0.20 2 .00 ± 1.14 0.774 9.92 ± 0.33 10.55 ± 0.32 0.803 7.58 ± 0.32 7.03 ± 0.46 0.571
24:0 1.12 ± 0.11 1.04 ± 0.17 0.775 0.11 ± 0.01 0.1 ± 0.01 0.803 0.05 ± 0.01 0.19 ± 0.03** 0.049
24:1n9 3.25 ± 0.14 3.27 ± 0.45 0.996 0.51 ± 0.08 0.5 ± 0.07 0.946 1.68 ± 0.19 1.4 ± 0.20 0.571
24:5n3 0.09 ± 0.00 0.11 ± 0.02 0.597 0.06 ± 0.00 0.05 ± 0.00 0.803 0.10 ± 0.01 0.12 ± 0.01 0.457
24:6n3 0.49 ± 0.03 0.61 ± 0.07* 0.546 0.16 ± 0.02 0.13 ± 0.01 0.803 0.41 ± 0.019 0.36 ± 0.04 0.501
ACL 18.39 ± 0.02 18.43 ± 0.06 0.775 18.31 ± 0.02 18.32 ± 0.03 0.9 18.53 ± 0.00 18.46 ± 0.01** 0.049
SFA 39.27 ± 0.35 38.03 ± 0.91 0.546 46.27 ± 0.66 46.95 ± 0.42 0.803 41.15 ± 0.24 42.45 ± 0.60* 0.228
UFA 60.73 ± 0.35 61.97 ± 0.91 0.546 53.73 ± 0.66 53.05 ± 0.42 0.803 58.85 ± 0.24 57.55 ± 0.60* 0.228
MUFA 46.61 ± 0.48 46.86 ± 2.88 0.874 29.16 ± 0.89 28.57 ± 1.17 0.813 35.36 ± 0.65 34.82 ± 1.06 0.738
PUFA 14.12 ± 0.46 15.11 ± 2.03 0.597 24.57 ± 0.44 24.48 ± 0.90 0.944 23.49 ± 0.48 22.73 ± 0.60 0.571
PUFAn3 2.79 ± 0.21 3.24 ± 1.05 0.597 10.59 ± 0.33 11.12 ± 0.34 0.803 8.81 ± 0.33 8.2 ± 0.44 0.571
PUFAn6 11.33 ± 0.26 11.87 ± 0.98 0.597 13.98 ± 0.26 13.36 ± 0.61 0.803 14.68 ± 0.31 14.53 ± 0.39 0.805
DBI 103.48 ± 2.01 108.63 ± 7.70 0.574 145.19 ± 1.90 145.55 ± 3.17 0.944 142.57 ± 1.87 137.95 ± 2.42 0.457
PI 59.9 ± 2.74 65.76 ± 12.88 0.597 135.75 ± 3.00 137.92 ± 4.95 0.813 122.52 ± 3.02 117.35 ± 4.36 0.571
SFA/UFA 0.65 ± 0.00 0.61 ± 0.02 0.546 0.86 ± 0.02 0.89 ± 0.01 0.803 0.7 ± 0.00 0.74 ± 0.01* 0.228
PβOx 3.69 ± 0.52 3.29 ± 7.47 0.775 74.66 ± 13.07 92.57 ± 14.00 0.803 19.17 ± 1.47 20.76 ± 6.38 0.716
FOREBRAIN
DIENCEPHALON SUBCORTICAL TELENCEPHALON
Thalamus Hippocampus Caudate Putamen
Middle-aged Elderly Sig Middle-aged Elderly Sig Middle-aged Elderly Sig Middle-aged Elderly Sig
14:0 0.67 ± 0.04 0.68 ± 0.04 0.976 0.88 ± 0.01 0.79 ± 0.18 0.759 0.63 ± 0.02 0.6 ± 0.07 0.671 0.62 ± 0.01 0.64 ± 0.05 0.809
16:0 18.08 ± 0.64 18.78 ± 0.91 0.934 20.99 ± 0.65 21.7 ± 0.65 0.759 21.46 ± 0.35 21.55 ± 0.50 0.932 19.39 ± 0.35 20.13 ± 0.57 0.568
16:1n7 1.34 ± 0.06 1.23 ± 0.14 0.761 1.26 ± 0.05 1.21 ± 0.22 0.759 0.92 ± 0.04 0.87 ± 0.05 0.673 0.89 ± 0.03 1.13 ± 0.11 0.309
18:0 23.36 ± 0.25 22.37 ± 0.59 0.687 22.01 ± 0.23 22.3 ± 0.39 0.759 25.41 ± 0.20 25.63 ± 0.98 0.693 24.05 ± 0.33 23.42 ± 0.37 0.470
18:1n9 23.06 ± 0.93 23.41 ± 1.55 0.937 20.88 ± 0.89 20.18 ± 1.21 0.759 17.43 ± 0.50 17.04 ± 0.64 0.762 18.49 ± 0.37 19.77 ± 0.98 0.470
18:1n7 4.51 ± 0.09 4.42 ± 0.30 0.934 4.69 ± 0.14 4.56 ± 0.28 0.759 4.69 ± 0.08 4.56 ± 0.11 0.682 4.48 ± 0.17 4.75 ± 0.12 0.520
18:2n6 0.66 ± 0.07 1.33 ± 0.59 0.687 0.64 ± 0.06 0.69 ± 0.05 0.759 1.03 ± 0.11 1.01 ± 0.10 0.942 1.08 ± 0.09 0.94 ± 0.21 0.632
18:3n3 0.09 ± 0.00 0.08 ± 0.00 0.761 0.06 ± 0.00 0.05 ± 0.01 0.759 0.07 ± 0.00 0.05 ± 0.00* 0.195 0.07 ± 0.00 0.07 ± 0.01 0.899
18:4n3 0.03 ± 0.00 0.04 ± 0.00 0.687 0.02 ± 0.00 0.02 ± 0.00 0.759 0.05 ± 0.00 0.04 ± 0.00 0.297 0.02 ± 0.00 0.02 ± 0.00 0.892
20:0 0.2 ± 0.00 0.33 ± 0.11 0.687 0.15 ± 0.01 0.15 ± 0.02 0.862 0.17 ± 0.00 0.2 ± 0.00* 0.195 0.17 ± 0.00 0.19 ± 0.01 0.394
20:1n9 1.74 ± 0.14 1.53 ± 0.25 0.796 1 ± 0.15 0.81 ± 0.39 0.759 0.85 ± 0.07 0.66 ± 0.10 0.297 1.03 ± 0.06 1.01 ± 0.14 0.934
20:2n6 0.36 ± 0.03 0.33 ± 0.04 0.687 0.45 ± 0.07 0.37 ± 0.08 0.759 0.17 ± 0.01 0.14 ± 0.02 0.368 0.22 ± 0.01 0.2 ± 0.02 0.763
20:3n6 0.9 ± 0.05 0.86 ± 0.08 0.796 1.25 ± 0.08 1.19 ± 0.07 0.759 1.03 ± 0.05 1.04 ± 0.07 0.935 1.03 ± 0.06 0.89 ± 0.06 0.394
20:4n6 7.76 ± 0.29 8.9 ± 1.03 0.687 8.82 ± 0.40 9.3 ± 0.70 0.759 9.23 ± 0.28 10.44 ± 0.42* 0.195 9.33 ± 0.21 9.45 ± 0.34 0.899
20:5n3 0.11 ± 0.01 0.11 ± 0.02 0.934 0.04 ± 0.01 0.04 ± 0.00 0.817 0.07 ± 0.00 0.08 ± 0.01 0.912 0.07 ± 0.01 0.06 ± 0.03 0.899
22:0 0.11 ± 0.01 0.18 ± 0.08 0.687 0.1 ± 0.01 0.09 ± 0.02 0.759 0.08 ± 0.00 0.07 ± 0.00 0.389 0.1 ± 0.00 0.09 ± 0.02 0.711
22:1n9 0.94 ± 0.03 0.81 ± 0.16 0.937 0.84 ± 0.10 0.55 ± 0.10* 0.705 1.32 ± 0.07 1.24 ± 0.12 0.671 1.02 ± 0.03 0.4 ± 0.25 0.579
22:4n6 5.12 ± 0.13 4.27 ± 0.26* 0.401 5.34 ± 0.09 4.96 ± 0.26* 0.705 4.72 ± 0.06 4.51 ± 0.11 0.297 5.38 ± 0.10 4.68 ± 0.27** 0.118
22:5n6 0.84 ± 0.08 0.6 ± 0.13 0.586 1.15 ± 0.11 1.03 ± 0.11 0.759 0.81 ± 0.06 0.63 ± 0.07 0.265 0.81 ± 0.05 0.56 ± 0.07* 0.202
22:5n3 0.34 ± 0.01 0.41 ± 0.04 0.586 0.3 ± 0.01 0.31 ± 0.02 0.759 0.28 ± 0.01 0.29 ± 0.02 0.673 0.31 ± 0.01 0.31 ± 0.01 0.987
22:6n3 7.69 ± 0.60 7.72 ± 0.96 0.937 7.64 ± 0.50 8.53 ± 0.93 0.759 8.52 ± 0.26 8.67 ± 0.34 0.839 10 ± 0.24 9.87 ± 0.57 0.899
24:0 0.34 ± 0.08 0.27 ± 0.05 0.796 0.03 ± 0.00 0.03 ± 0.09 0.759 0.17 ± 0.02 0.09 ± 0.01* 0.195 0.02 ± 0.00 0.02 ± 0.03* 0.309
24:1n9 1.39 ± 0.24 1.04 ± 0.23 0.694 1.14 ± 0.20 0.89 ± 0.20 0.759 0.69 ± 0.08 0.45 ± 0.08 0.27 1.14 ± 0.10 1.06 ± 0.20 0.899
24:5n3 0.05 ± 0.00 0.07 ± 0.00* 0.511 0.04 ± 0.00 0.04 ± 0.00 0.890 0.06 ± 0.00 0.06 ± 0.00 0.666 0.04 ± 0.00 0.06 ± 0.00 0.311
24:6n3 0.32 ± 0.04 0.25 ± 0.03 0.687 0.26 ± 0.04 0.2 ± 0.02 0.759 0.14 ± 0.01 0.09 ± 0.01* 0.195 0.26 ± 0.03 0.28 ± 0.05 0.899
ACL 18.53 ± 0.01 18.47 ± 0.01* 0.416 18.46 ± 0.01 18.44 ± 0.03 0.759 18.45 ± 0.00 18.44 ± 0.01 0.601 18.6 ± 0.01 18.51 ± 0.02** 0.167
SFA 42.75 ± 0.62 42.6 ± 1.26 0.937 44.17 ± 0.69 45.06 ± 0.71 0.759 47.91 ± 0.33 48.13 ± 0.50 0.839 44.35 ± 0.31 44.49 ± 0.91 0.913
UFA 57.25 ± 0.62 57.4 ± 1.26 0.937 55.83 ± 0.69 54.94 ± 0.71 0.759 52.09 ± 0.33 51.87 ± 0.50 0.839 55.65 ± 0.31 55.51 ± 0.91 0.913
MUFA 32.98 ± 1.34 32.44 ± 2.05 0.937 29.82 ± 1.30 28.21 ± 2.38 0.759 25.91 ± 0.71 24.82 ± 0.78 0.601 27.04 ± 0.55 28.12 ± 1.32 0.711
PUFA 24.27 ± 0.75 24.96 ± 1.06 0.796 26.01 ± 0.66 26.73 ± 1.82 0.759 26.18 ± 0.48 27.05 ± 0.47 0.535 28.61 ± 0.29 27.39 ± 0.63 0.319
PUFAn3 8.64 ± 0.58 8.68 ± 0.90 0.937 8.36 ± 0.47 9.19 ± 0.90 0.759 9.2 ± 0.24 9.28 ± 0.35 0.912 10.77 ± 0.20 10.66 ± 0.50 0.899
PUFAn6 15.64 ± 0.28 16.28 ± 1.30 0.796 17.65 ± 0.35 17.54 ± 0.94 0.863 16.98 ± 0.30 17.78 ± 0.41 0.379 17.84 ± 0.30 16.73 ± 0.29** 0.167
DBI 144.4 ± 2.97 145.16 ± 3.27 0.956 147.71 ± 2.51 150.64 ± 7.02 0.759 145.67 ± 1.56 148.21 ± 1.78 0.601 159.55 ± 0.88 155.72 ± 2.94 0.319
PI 127.6 ± 5.46 128.06 ± 6.90 0.976 133.56 ± 4.69 139.7 ± 11.29 0.759 136.66 ± 2.59 140.35 ± 2.68 0.625 152.54 ± 1.55 147.47 ± 4.76 0.470
SFA/UFA 0.75 ± 0.01 0.74 ± 0.04 0.937 0.79 ± 0.02 0.82 ± 0.02 0.759 0.92 ± 0.01 0.93 ± 0.01 0.839 0.8 ± 0.01 0.8 ± 0.03 0.899
PβOx 29.85 ± 3.86 33.91 ± 6.53 0.934 37.07 ± 6.16 48.54 ± 9.09 0.759 70.59 ± 11.74 109.16 ± 14.86 0.249 43.02 ± 5.80 48.88 ± 10.68 0.892
FOREBRAIN
CORTICAL TELENCEPHALON
Occipital cortex Parietal cortex Temporal cortex
Middle-aged Elderly Sig Middle-aged Elderly Sig Middle-aged Elderly Sig
14:0 0.81 ± 0.03 0.7 ± 0.04 0.494 0.84 ± 0.04 0.7 ± 0.02* 0.557 0.82 ± 0.01 0.85 ± 0.03 0.773
16:0 21.76 ± 0.36 21.18 ± 0.37 0.825 21.11 ± 0.57 20.56 ± 0.49 0.846 24.73 ± 0.36 24.11 ± 0.83 0.503
16:1n7 1.17 ± 0.06 1.02 ± 0.13 0.705 1.3 ± 0.07 1.14 ± 0.07 0.846 0.98 ± 0.05 0.94 ± 0.10 0.773
18:0 24.52 ± 0.26 23.74 ± 0.49 0.494 24.38 ± 0.39 24.28 ± 0.38 0.973 24.87 ± 0.18 25.09 ± 0.12 0.756
18:1n9 17.89 ± 0.58 18.54 ± 0.92 0.977 19.72 ± 0.81 19.85 ± 0.63 0.973 15.11 ± 0.42 16.28 ± 0.69 0.231
18:1n7 3.94 ± 0.11 4.00 ± 0.19 0.982 4.3 ± 0.10 4.3 ± 0.26 0.996 3.33 ± 0.06 3.51 ± 0.19 0.699
18:2n6 1.05 ± 0.12 1.15 ± 0.12 0.977 1.21 ± 0.11 1.21 ± 0.13 0.996 0.94 ± 0.10 1.05 ± 0.10 0.773
18:3n3 0.06 ± 0.00 0.06 ± 0.00 0.982 0.08 ± 0.00 0.07 ± 0.00 0.846 0.04 ± 0.00 0.04 ± 0.00 0.978
18:4n3 0.03 ± 0.00 0.04 ± 0.00 0.494 0.04 ± 0.00 0.04 ± 0.00 0.973 0.03 ± 0.00 0.03 ± 0.00 0.823
20:0 0.19 ± 0.00 0.21 ± 0.00 0.494 0.21 ± 0.00 0.2 ± 0.00 0.973 0.16 ± 0.00 0.18 ± 0.00* 0.147
20:1n9 1.03 ± 0.09 1.02 ± 0.11 0.987 1.19 ± 0.16 1.04 ± 0.16 0.863 0.46 ± 0.05 0.52 ± 0.17 0.773
20:2n6 0.25 ± 0.02 0.21 ± 0.02 0.817 0.30 ± 0.03 0.25 ± 0.01 0.846 0.16 ± 0.01 0.15 ± 0.05 0.773
20:3n6 0.99 ± 0.05 0.97 ± 0.07 0.982 1.08 ± 0.054 1.02 ± 0.07 0.863 1.11 ± 0.07 1.02 ± 0.06 0.756
20:4n6 7.33 ± 0.23 7.38 ± 0.31 0.982 7.71 ± 0.32 8.02 ± 0.27 0.876 9.96 ± 0.31 9.1 ± 0.41 0.231
20:5n3 0.06 ± 0.012 0.06 ± 0.00 0.982 0.07 ± 0.00 0.06 ± 0.02 0.921 0.08 ± 0.01 0.07 ± 0.00 0.773
22:0 0.09 ± 0.00 0.10 ± 0.00 0.982 0.11 ± 0.01 0.11 ± 0.01 0.973 0.05 ± 0.00 0.06 ± 0.01 0.756
22:1n9 2.18 ± 0.10 2.28 ± 0.27 0.982 0.74 ± 0.04 0.48 ± 0.07 0.846 0.86 ± 0.39 1.07 ± 0.20 0.782
22:4n6 3.9 ± 0.13 3.51 ± 0.12 0.494 4.08 ± 0.13 3.88 ± 0.12 0.846 4.43 ± 0.11 4.04 ± 0.15* 0.173
22:5n6 0.78 ± 0.05 0.65 ± 0.09 0.592 0.84 ± 0.09 0.72 ± 0.09 0.846 0.96 ± 0.08 0.66 ± 0.06* 0.164
22:5n3 0.33 ± 0.01 0.37 ± 0.02 0.502 0.3 ± 0.01 0.34 ± 0.03 0.759 0.34 ± 0.02 0.36 ± 0.03 0.773
22:6n3 10.49 ± 0.29 11.69 ± 0.59 0.502 8.95 ± 0.43 10.37 ± 0.46 0.557 10.04 ± 0.27 10.4 ± 0.57 0.756
24:0 0.14 ± 0.019 0.13 ± 0.032 0.982 0.22 ± 0.04 0.2 ± 0.03 0.973 0.04 ± 0.00 0.06 ± 0.04 0.509
24:1n9 0.80 ± 0.10 0.80 ± 0.16 0.987 0.97 ± 0.22 0.83 ± 0.13 0.936 0.24 ± 0.06 0.28 ± 0.22 0.773
24:5n3 0.04 ± 0.00 0.03 ± 0.00 0.792 0.05 ± 0.00 0.07 ± 0.01 0.742 0.06 ± 0.00 0.04 ± 0.00* 0.147
24:6n3 0.16 ± 0.01 0.17 ± 0.02 0.982 0.19 ± 0.02 0.26 ± 0.07 0.846 0.19 ± 0.02 0.09 ± 0.03** 0.057
ACL 18.49 ± 0.01 18.54 ± 0.01* 0.494 18.42 ± 0.02 18.47 ± 0.01 0.557 18.39 ± 0.01 18.38 ± 0.02 0.773
SFA 47.51 ± 0.47 46.05 ± 0.71 0.494 46.88 ± 0.76 46.05 ± 0.78 0.846 50.68 ± 0.46 50.35 ± 0.77 0.773
UFA 52.49 ± 0.47 53.95 ± 0.71 0.494 53.12 ± 0.76 53.95 ± 0.78 0.846 49.32 ± 0.46 49.65 ± 0.77 0.773
MUFA 27.02 ± 0.85 27.66 ± 1.38 0.982 28.22 ± 1.23 27.66 ± 1.17 0.973 20.98 ± 0.71 22.6 ± 1.53 0.254
PUFA 25.48 ± 0.48 26.3 ± 0.85 0.825 24.91 ± 0.54 26.3 ± 0.43 0.646 28.34 ± 0.46 27.06 ± 0.86 0.231
PUFAn3 11.17 ± 0.29 12.43 ± 0.58 0.494 9.68 ± 0.41 11.19 ± 0.42* 0.557 10.77 ± 0.31 11.03 ± 0.57 0.773
PUFAn6 14.3 ± 0.39 13.86 ± 0.30 0.793 15.22 ± 0.36 15.11 ± 0.30 0.973 17.57 ± 0.42 16.02 ± 0.33* 0.147
DBI 147.77 ± 1.58 153.92 ± 3.38 0.500 143.21 ± 1.98 151.26 ± 1.78* 0.557 152.85 ± 1.72 149.47 ± 3.06 0.517
PI 141.57 ± 2.60 149.4 ± 5.77 0.705 132.58 ± 3.79 144.17 ± 3.66 0.557 152.02 ± 2.57 147.29 ± 5.51 0.517
SFA/UFA 0.91 ± 0.01 0.85 ± 0.024 0.494 0.89 ± 0.02 0.85 ± 0.02 0.846 1.03 ± 0.01 1.01 ± 0.02 0.773
PβOx 84.36 ± 14.11 80.57 ± 17.42 0.982 58.46 ± 12.84 60.12 ± 13.10 0.973 61.01 ± 11.706 135.92 ± 22.40** 0.057
FOREBRAIN
CORTICAL TELENCEPHALON
Entorhinal cortex Frontal cortex Cingulate cortex
Middle-aged Elderly Sig Middle-aged Elderly Sig Middle-aged Elderly Sig
14:0 0.79 ± 0.03 0.81 ± 0.03 0.866 0.84 ± 0.04 0.77 ± 0.04 0.953 0.95 ± 0.05 0.87 ± 0.03 0.934
16:0 20.98 ± 0.66 20.03 ± 0.85 0.695 22.16 ± 0.51 22.09 ± 0.36 0.964 23.73 ± 0.93 22.52 ± 0.80 0.934
16:1n7 1.29 ± 0.07 1.52 ± 0.17 0.691 1.38 ± 0.08 1.28 ± 0.08 0.953 1.38 ± 0.12 1.52 ± 0.15 0.934
18:0 24.38 ± 0.27 23.82 ± 0.36 0.691 24.33 ± 0.26 24.28 ± 0.49 0.964 22.79 ± 0.41 22.49 ± 0.42 0.934
18:1n9 18.74 ± 0.95 20.86 ± 1.28 0.691 17.94 ± 0.84 18.03 ± 0.56 0.964 18.56 ± 1.18 19.53 ± 0.87 0.934
18:1n7 4.05 ± 0.16 4.11 ± 0.22 0.908 3.91 ± 0.11 3.85 ± 0.25 0.964 3.97 ± 0.11 4.14 ± 0.28 0.934
18:2n6 0.78 ± 0.08 0.83 ± 0.09 0.866 1.13 ± 0.07 1.12 ± 0.10 0.964 0.81 ± 0.10 0.86 ± 0.08 0.934
18:3n3 0.05 ± 0.00 0.06 ± 0.00 0.695 0.06 ± 0.00 0.05 ± 0.00 0.953 0.06 ± 0.00 0.07 ± 0.00 0.934
18:4n3 0.03 ± 0.00 0.03 ± 0.00 0.759 0.04 ± 0.00 0.03 ± 0.00 0.953 0.03 ± 0.00 0.03 ± 0.00 0.934
20:0 0.21 ± 0.00 0.23 ± 0.01 0.691 0.25 ± 0.08 0.19 ± 0.01 0.953 0.19 ± 0.00 0.22 ± 0.00** 0.376
20:1n9 0.88 ± 0.15 1.06 ± 0.14 0.705 0.82 ± 0.10 0.76 ± 0.09 0.964 0.94 ± 0.23 1.07 ± 0.18 0.934
20:2n6 0.31 ± 0.04 0.32 ± 0.03 0.975 0.24 ± 0.02 0.21 ± 0.03 0.953 0.3 ± 0.04 0.28 ± 0.04 0.934
20:3n6 1.02 ± 0.07 0.97 ± 0.06 0.851 1.05 ± 0.04 0.99 ± 0.10 0.953 1 ± 0.05 0.98 ± 0.07 0.970
20:4n6 8.91 ± 0.37 8.17 ± 0.34 0.691 8.38 ± 0.30 8.56 ± 0.28 0.964 8.12 ± 0.30 7.75 ± 0.35 0.934
20:5n3 0.06 ± 0.00 0.06 ± 0.01 0.866 0.08 ± 0.01 0.05 ± 0.00 0.953 0.06 ± 0.01 0.05 ± 0.01 0.934
22:0 0.09 ± 0.01 0.12 ± 0.01 0.691 0.08 ± 0.00 0.08 ± 0.00 0.953 0.08 ± 0.01 0.09 ± 0.01 0.934
22:1n9 0.7 ± 0.04 0.62 ± 0.06 0.691 1.04 ± 0.12 0.96 ± 0.07 0.964 0.75 ± 0.07 0.72 ± 0.07 0.934
22:4n6 4.94 ± 0.10 4.75 ± 0.17 0.691 4.1 ± 0.11 3.91 ± 0.23 0.953 4.72 ± 0.14 4.48 ± 0.15 0.934
22:5n6 0.88 ± 0.05 0.68 ± 0.13 0.691 0.96 ± 0.10 0.73 ± 0.16 0.953 1.03 ± 0.12 0.78 ± 0.08 0.934
22:5n3 0.3 ± 0.01 0.31 ± 0.02 0.908 0.31 ± 0.01 0.34 ± 0.02 0.953 0.3 ± 0.02 0.32 ± 0.02 0.934
22:6n3 9.29 ± 0.44 8.72 ± 0.78 0.763 9.97 ± 0.49 10.87 ± 0.53 0.953 9.08 ± 0.62 9.84 ± 0.57 0.934
24:0 0.23 ± 0.053 0.34 ± 0.07 0.691 0.16 ± 0.03 0.14 ± 0.02 0.964 0.2 ± 0.08 0.22 ± 0.04 0.970
24:1n9 0.85 ± 0.19 1.32 ± 0.31 0.691 0.58 ± 0.17 0.54 ± 0.11 0.964 0.74 ± 0.29 0.93 ± 0.24 0.934
24:5n3 0.04 ± 0.00 0.05 ± 0.00 0.695 0.05 ± 0.00 0.04 ± 0.00 0.953 0.04 ± 0.00 0.04 ± 0.00 0.934
24:6n3 0.17 ± 0.03 0.23 ± 0.04 0.695 0.13 ± 0.02 0.12 ± 0.01 0.964 0.15 ± 0.04 0.18 ± 0.03 0.934
ACL 18.48 ± 0.01 18.48 ± 0.01 0.975 18.43 ± 0.00 18.44 ± 0.01 0.953 18.38 ± 0.02 18.42 ± 0.01 0.934
SFA 46.68 ± 0.82 45.36 ± 1.07 0.691 47.83 ± 0.60 47.56 ± 0.52 0.964 47.95 ± 1.10 46.41 ± 0.91 0.934
UFA 53.32 ± 0.82 54.64 ± 1.07 0.691 52.17 ± 0.60 52.44 ± 0.52 0.964 52.05 ± 1.10 53.59 ± 0.91 0.934
MUFA 26.52 ± 1.39 29.48 ± 2.00 0.691 25.68 ± 1.20 25.42 ± 0.86 0.964 26.34 ± 1.90 27.93 ± 1.58 0.934
PUFA 26.8 ± 0.58 25.16 ± 0.95 0.691 26.49 ± 0.68 27.02 ± 0.41 0.953 25.71 ± 0.85 25.67 ± 0.69 0.970
PUFAn3 9.95 ± 0.41 9.45 ± 0.73 0.787 10.63 ± 0.47 11.5 ± 0.53 0.953 9.73 ± 0.59 10.53 ± 0.56 0.934
PUFAn6 16.85 ± 0.26 15.71 ± 0.33* 0.691 15.86 ± 0.32 15.52 ± 0.63 0.953 15.98 ± 0.34 15.13 ± 0.46 0.934
DBI 150.66 ± 2.00 145.79 ± 3.38 0.691 149.4 ± 2.67 152.96 ± 1.19 0.953 145.79 ± 2.83 148.5 ± 2.14 0.934
PI 142.85 ± 4.21 133.85 ± 6.83 0.691 143.49 ± 4.71 148.97 ± 2.63 0.953 137.84 ± 5.74 140.32 ± 4.55 0.934
SFA/UFA 0.88 ± 0.02 0.83 ± 0.03 0.691 0.92 ± 0.02 0.91 ± 0.01 0.964 0.93 ± 0.03 0.87 ± 0.03 0.934
PβOx 79.71 ± 15.08 58.42 ± 20.69 0.732 91.97 ± 13.39 105.31 ± 16.42 0.953 84.06 ± 12.88 75.12 ± 18.50 0.934