Table 2.
Associations between lipids and APOE genotype among Health ABC Black men
| Mean (standard error) of APOE genotype categories | Overall p-valuea; pairwise comparisonsb | ||||
|---|---|---|---|---|---|
| ε2 carriers (n = 58) | ε3 homozygotes (n = 137) | ε4 carrier (n = 83) | ε2ε4 carriers (n = 14) | ||
| Monoacylglycerol (MAG) score | − 0.38 (0.10) | 0.19 (0.10) | 0.0007 (0.10) | − 0.24 (0.16) | 0.0005c; ε2 < ε4, ε3 |
| Cholesteryl ester (CE) score | − 0.38 (0.13) | 0.08 (0.09) | 0.14 (0.11) | − 0.04 (0.26) | 0.005c; ε2 < ε3, ε4 |
| Sphingosine | − 0.23 (0.13) | 0.18 (0.08) | − 0.06 (0.11) | − 0.49 (0.26) | .02c; ε2 < ε3 |
| Triacylglycerol (TAG) that consist mostly of polyunsaturated fatty acids score | 0.29 (0.13) | − 0.05 (0.09) | − 0.15 (0.11) | 0.17 (0.27) | 0.03c; ε2 > ε3, ε4 |
| Free carnitine | 0.06 (0.13) | 0.12 (0.09) | − 0.23 (0.11) | − 0.06 (0.27) | .04c; ε4 < ε3 |
| PE plasmalogen score | 0.23 (0.13) | − 0.02 (0.09) | − 0.17 (0.11) | 0.25 (0.27) | 0.07 |
| Lysophosphatidylethanolamine (LPE) score | 0.10 (0.12) | − 0.15 (0.09) | 0.10 (0.10) | 0.46 (0.26) | 0.11 |
| PS plasmalogen score | − 0.20 (0.13) | 0.10 (0.09) | − 0.04 (0.11) | 0.11 (0.27) | 0.16 |
| Sphingomyelin (SM) score | − 0.22 (0.13) | 0.05 (0.09) | 0.06 (0.11) | 0.12 (0.27) | 0.18 |
| PC plasmalogen score | 0.07 (0.13) | 0.04 (0.09) | − 0.18 (0.11) | 0.40 (0.27) | 0.22 |
| 3-methyladipate | 0.21 (0.16) | − 0.03 (0.08) | − 0.10 (0.11) | − 0.006 (0.25) | 0.28 |
| Phosphorylcholine (PC) score | − 0.19 (0.13) | 0.06 (0.09) | − 0.008 (0.11) | 0.24 (0.27) | 0.30 |
| Mevalonic acid | 0.11 (0.13) | − 0.09 (0.09) | 0.07 (0.11) | − 0.02 (0.27) | 0.32 |
| Lysophosphatidylcholine (LPC) score | 0.05 (0.13) | − 0.10 (0.09) | 0.06 (0.11) | 0.42 (0.27) | 0.47 |
| Alpha-glycerophosphocholine | 0.13 (0.13) | − 0.02 (0.09) | − 0.08 (0.11) | 0.12 (0.27) | 0.48 |
| Phosphatidylinositol (PI) score | − 0.12 (0.13) | 0.05 (0.09) | − 0.03 (0.11) | 0.15 (0.27) | 0.57 |
| Acylcarnitine score | 0.04 (0.13) | 0.05 (0.09) | − 0.09 (0.11) | − 0.11 (0.27) | 0.61 |
| Phosphatidylethanolamine (PE) score | 0.09 (0.13) | − 0.002 (0.09) | − 0.04 (0.11) | − 0.10 (0.27) | 0.73 |
| Bile acid score | − 0.01 (0.13) | − 0.0005 (0.09) | 0.09 (0.11) | − 0.49 (0.27) | 0.75 |
| Diacylglycerol (DAG) score | 0.08 (0.13) | 0.006 (0.08) | − 0.04 (0.11) | − 0.16 (0.27) | 0.78 |
| Alpha-glycerophosphate | 0.01 (0.13) | − 0.02 (0.09) | 0.06 (0.11) | − 0.18 (0.27) | 0.86 |
| C34:0 PS | − 0.09 (0.13) | − 0.002 (0.09) | − 0.02 (0.11) | 0.47 (0.27) | 0.87 |
| Adipate | 0.02 (0.13) | − 0.02 (0.09) | 0.03 (0.11) | − 0.11 (0.27) | 0.94 |
| Triacylglycerol (TAG) that do not consist mostly of polyunsaturated fatty acids score | 0.02 (0.13) | 0.006 (0.08) | − 0.002 (0.11) | − 0.14 (0.27) | 0.99 |
| Ceramide score | 0.0007 (0.13) | − 0.001 (0.09) | 0.004 (0.11) | − 0.01 (0.27) | 0.999 |
APOE, Apolipoprotein E; PE, phosphatidylethanolamine; PS, phosphatidylserine; PC, phosphorylcholine
aExcluding n = 14 participants with APOE genotype ε2ε4
bε2 denotes ε2 carriers (ε2ε2 and ε2ε3); ε3 denotes ε3 homozygotes (ε3ε3), and ε4 denotes ε4 carriers (ε3ε4 and ε4ε4)
cFalse discovery rate < 0.30