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. 2022 May 13;12:894644. doi: 10.3389/fcimb.2022.894644

Table 1.

Effect of in vivo depletion or knockout of key neutrophil migration mediators on neutrophil influx, survival and bacterial burden in pneumococcal pneumonia.

Influx Host Survival Burden
Detection
TLRs
TLR2 NS NS (Branger et al., 2004; Dessing et al., 2008a).
TLR4 NS NS (Dessing et al., 2008b; Knapp et al., 2004)
TLR9 NS (Albiger et al., 2007)
TLR adaptor MyD88 (Albiger et al., 2005)
NODs NOD1 NS NS NS (Lysenko et al., 2007)
NOD2 NS (Davis et al., 2011)
NF-κB (Alcamo et al., 2001)
TLR2 & NOD2 (Davis et al., 2011)
Migration
Integrins
CD18/CD11 NS (Mizgerd et al., 1997; Mizgerd et al., 1999)
LFA-1 NS NS (Kadiolglu et al., 2011b)
VLA-4 NS (Kubes et al., 1995)
Mac-1 (Ren et al., 2004; Kadioglu et al., 2011b)
Ligands E-selectin NS (Mizgerd et al., 1996)
P-selectin NS (Mizgerd et al., 1996)
PSGL-1 NS (Ramos-Sevillano et al., 2016)
ICAM-1 NS (Bullard et al., 1995; Kadioglu et al., 2011b)
VCAM-1 NS (Moreland et al., 2004)
L-selectin NS (Doyle et al., 1997)
Galectin-3 (Nieminen et al., 2008)
P-selectin & ICAM-1 NS (Mizgerd et al., 1996)
Chemoattractants CXCL1 (Paudel et al., 2019)
Chemokines CXCR2 (Herbold et al., 2010)
Lipids HXA3 (Bhowmick et al., 2017; Adams et al., 2020)
LTB4 (Mancuso et al., 2010)
Signaling
Cytokines
IL-17a (Ritchie et al., 2018)
TNF-α NS (Takashima et al., 1997; Jeong et al., 2015)
IL-10 (Peñaloza et al., 2015)

↓ decreased; ↑ increased; - not determined; NS, no significant difference.