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The mechanisms of IL-38 and ischemic injury and repair after MI. (A) The mechanism of IL-38 on cardiomyocytes during ventricular remodeling. (B) The mechanism of IL-38 on tDCs during ventricular remodeling. MIRI, myocardial ischemia–reperfusion injury; IL-38, interleukin-38; IFN-γ, interferon-γ; tDCs, tolerogenic dendritic cells; Treg cells, regulatory T cells; (+), promoting effect; (-), inhibition.
