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Summary of kinetic parameters for hOAT using various substrates
| Substrate | Limiting rate constant (klim) | Dissociation constant (Kd) | klim/Kd |
|---|---|---|---|
| l-Orn | 48.6 ± 1.2 s−1 | 4700 ± 290 μM | 10,340 ± 687 M−1 s−1 |
| AVA | 0.097 ± 0.003 s−1 | 735 ± 78 μM | 131.9 ± 14.6 M−1 s−1 |
| DABA | ND | ND | 0.249 ± 0.006 M−1 s−1 |
| GABA | ND | 110 ± 15 μM | ND |
Abbreviation: ND, not determined.
