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. 2022 May 13;12:913254. doi: 10.3389/fonc.2022.913254

Table 3.

Results of univariate and multivariable Cox proportional regression analysis of EOR and PORT in different age groups.

Patient groups			Univariate Analysis		Multivariable Analysis
Patient groups			HR (95% CI)	P-value	HR (95% CI)	P-value
EOR	<65 years	GTR	1 [Reference]		1 [Reference]
		Biopsy	4.23 (1.13–15.81)	0.032^†	6.47 (1.42–29.44)	0.018^†
		STR	2.66 (0.93–7.69)	0.069	2.77 (0.81–9.48)	0.103
	≥65 years	GTR	1 [Reference]		1 [Reference]
		Biopsy	2.07 (0.89–4.82)	0.091	3.72 (1.35–10.21)	0.011^†
		STR	1.09 (0.51–2.35)	0.808	0.83 (0.37–1.86)	0.653
PORT	<65 years	No/unknown	1 [Reference]		1 [Reference]
	<65 years	Beam radiation	1.36 (0.56–3.31)	0.493	2.29 (0.27–19.05)	0.442
	≥65 years	No/unknown	1 [Reference]		1 [Reference]
	≥65 years	Beam radiation	1.06 (0.53–2.13)	0.865	0.94 (0.42–2.12)	0.888

^†P < 0.05, statistically significant.

EOR, extent of surgery; GTR, gross total resection; STR, subtotal resection; PORT, postoperative radiotherapy.