Table 1.

Inhibitory activities and toxicities of microtubule inhibitors, daclatasvir and ledipasvir in BM45-Feo replicon cells.

Compound	24 h (nM, mean $\pm$ SD)		48 h (nM, mean $\pm$ SD)
	IC50a	TC50b	IC50a	TC50b
Colchicine	57.49 $\pm$ 18.56	>10000	4.14 $\pm$ 1.29	78.19 $\pm$ 45.58
27a	15.51 $\pm$ 12.01	>10000	33.88 $\pm$ 13.45	128.04 $\pm$ 94.46
27b	68.90 $\pm$ 42.42	>10000	33.98 $\pm$ 11.90	119.93 $\pm$ 46.70
9f	20.1 $\pm$ 13.81	>10000	13.37 $\pm$ 2.86	4804.67 $\pm$ 1175.25
19a	130.8 $\pm$ 6.56	>10000	57.41 $\pm$ 36.76	4868.25 $\pm$ 1885.84
31b	112.46 $\pm$ 97.93	>10000	389.97 $\pm$ 86.79	2794.33 $\pm$ 1066.43
31d	754.43 $\pm$ 428.06	>10000	294.87 $\pm$ 9.31	6233.33 $\pm$ 2091.71
Daclatasvir	0.14 $\pm$ 0.16	>10000	0.038 $\pm$ 0.0087	>10000
Ledipasvir	0.08 $\pm$ 0.03	>10000	0.0097 $\pm$ 0.0021	>10000

^aIC₅₀: The concentration of a compound required for 50% inhibition of HCV replication.

^bTC₅₀: The concentration of a compound required to cause 50% cell death.