TABLE 3.
List of pathways significantly enriched from hypo‐phosphorylated proteins upon inhibition of CAMKK2 in gastric cancer cells.
| Pathway identifier | Pathway name | #Entities found | Entities p-Value | Entities FDR |
|---|---|---|---|---|
| R-HSA-9006934 | Signaling by receptor tyrosine kinases | 35 | 8.7597E-14 | 8.584E-11 |
| R-HSA-1059683 | Interleukin-6 signaling | 8 | 1.7371E-10 | 8.512E-08 |
| R-HSA-422475 | Axon guidance | 29 | 3.6484E-09 | 8.939E-07 |
| R-HSA-449147 | Signaling by interleukins | 30 | 6.7668E-09 | 1.326E-06 |
| R-HSA-194138 | Signaling by VEGF | 14 | 9.7167E-09 | 1.584E-06 |
| R-HSA-1280215 | Cytokine signaling in immune system | 44 | 1.164E-08 | 1.63E-06 |
| R-HSA-6783589 | Interleukin-6 family signaling | 8 | 1.4004E-08 | 1.708E-06 |
| R-HSA-4420097 | VEGFA–VEGFR2 pathway | 13 | 3.5198E-08 | 3.449E-06 |
| R-HSA-446728 | Cell junction organization | 11 | 1.1816E-07 | 1.052E-05 |
| R-HSA-3928665 | EPH-ephrin–mediated repulsion of cells | 8 | 1.3293E-06 | 8.652E-05 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 5 | 1.331E-06 | 8.652E-05 |
| R-HSA-2682334 | EPH-Ephrin signaling | 10 | 1.9793E-06 | 0.0001185 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 6 | 3.2771E-06 | 0.000177 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 16 | 5.2327E-06 | 0.0002564 |
| R-HSA-5683057 | MAPK family signaling cascades | 17 | 9.3806E-06 | 0.0004127 |
| R-HSA-112411 | MAPK1 (ERK2) activation | 4 | 2.7673E-05 | 0.0007472 |
| R-HSA-166520 | Signaling by NTRKs | 9 | 4.9175E-05 | 0.0011539 |
| R-HSA-8848021 | Signaling by PTK6 | 7 | 7.1858E-05 | 0.001509 |