TABLE 4.
List of significantly hypo‐phosphorylated (tyrosine) proteins upon inhibition of CAMKK2 involved in VEGF and VEGFA–VEGFR pathways.
| Gene | Sequence | Site | PSM a | FC(T/C) | P-value |
|---|---|---|---|---|---|
| PRKCD | [R].RSDSASSEPVGIYQGFEK.[K] | Y332 | 2 | 0.0001 | 9E-06 |
| PXN | [R].VGEEEHVYSFPNK.[Q] | Y124 | 230 | 0.54 | 2E-02 |
| CTNND1 | [K].SLDNNYSTPNER.[G] | Y904 | 20 | 0.17 | 9E-04 |
| SHB | [K].LPQDDDRPADEYDQPWEWNR.[V] | Y336 | 8 | 0.19 | 1E-01 |
| MAPK14 | [R].HTDDEMTGYVATR.[W] | Y223 | 88 | 0.65 | 2E-02 |
| PTK2 | [R].YMEDSTYYK.[A] | Y662 | 92 | 0.22 | 2E-04 |
| MAPK13 | [R].HADAEMTGYVVTR.[W] | Y182 | 22 | 1.61 | 3E-01 |
| SNRNP70 | [R].EFEVYGPIKR.[I] | Y126 | 74 | 1.54 | 2E-02 |
| NUCB1 | [R].YEMLKEHER.[R] | Y179 | 6 | 0.05 | 3E-03 |
| PTK2B | [R].YIEDEDYYKASVTRLPIK.[W] | Y579 | 16 | 4.61 | 4E-02 |
| CTNNB1 | [R].LHYGLPVVVK.[L] | Y489 | 8 | 1.82 | 1E-01 |
| CALM2 | [R].VFDKDGNGYISAAELR.[H] | Y148 | 43 | 2.56 | 9E-03 |
| DOCK1 | [K].GSVADYGNLMENQDLLGSPTPPPPPPHQR.[H] | Y1854 | 10 | 0.0001 | 1E-01 |
| BCAR1 | [R].VLPPEVADGGVVDSGVYAVPPPAER.[E] | Y456 | 7 | 0.43 | 1E-01 |
a
PSM = Peptide-Spectrum Match