TABLE 1.
Correlations among the four immune clusters and clinical characteristics in the TCGA-LGG dataset.
| Covariates | Cluster | Total | A | B | C | D | p value |
|---|---|---|---|---|---|---|---|
| Age | <40 | 221 (45.95%) | 84 (43.3%) | 85 (54.49%) | 28 (45.16%) | 24 (34.78%) | 0.035 |
| ≥40 | 260 (54.05%) | 110 (56.7%) | 71 (45.51%) | 34 (54.84%) | 45 (65.22%) | ||
| Gender | FEMALE | 214 (44.49%) | 95 (48.97%) | 60 (38.46%) | 28 (45.16%) | 31 (44.93%) | 0.2738 |
| MALE | 267 (55.51%) | 99 (51.03%) | 96 (61.54%) | 34 (54.84%) | 38 (55.07%) | ||
| Grade | G2 | 230 (47.82%) | 107 (55.15%) | 83 (53.21%) | 28 (45.16%) | 12 (17.39%) | 0 |
| G3 | 251 (52.18%) | 87 (44.85%) | 73 (46.79%) | 34 (54.84%) | 57 (82.61%) | ||
| IDH1 R132 status | Mutation | 368 (76.51%) | 161 (82.99%) | 135 (86.54%) | 37 (59.68%) | 35 (50.72%) | 0 |
| Wild | 113 (23.49%) | 33 (17.01%) | 21 (13.46%) | 25 (40.32%) | 34 (49.28%) | ||
| IDH2 R172 status | Mutation | 20 (4.16%) | 12 (6.19%) | 6 (3.85%) | 1 (1.61%) | 1 (1.45%) | 0.2292 |
| Wild | 461 (95.84%) | 182 (93.81%) | 150 (96.15%) | 61 (98.39%) | 68 (98.55%) | ||
| PTEN status | Mutation | 29 (6.03%) | 5 (2.58%) | 8 (5.13%) | 4 (6.45%) | 12 (17.39%) | 2.00E-04 |
| Wild | 452 (93.97%) | 189 (97.42%) | 148 (94.87%) | 58 (93.55%) | 57 (82.61%) | ||
| EGFR status | Mutation | 30 (6.24%) | 7 (3.61%) | 6 (3.85%) | 6 (9.68%) | 11 (15.94%) | 0.001 |
| Wild | 451 (93.76%) | 187 (96.39%) | 150 (96.15%) | 56 (90.32%) | 58 (84.06%) | ||
| ATRX status | Mutation | 174 (36.17%) | 45 (23.2%) | 83 (53.21%) | 26 (41.94%) | 20 (28.99%) | 0 |
| Wild | 307 (63.83%) | 149 (76.8%) | 73 (46.79%) | 36 (58.06%) | 49 (71.01%) | ||
| TP53 status | Mutation | 216 (44.91%) | 66 (34.02%) | 92 (58.97%) | 29 (46.77%) | 29 (42.03%) | 1.00E-04 |
| Wild | 265 (55.09%) | 128 (65.98%) | 64 (41.03%) | 33 (53.23%) | 40 (57.97%) |